生物活性玻璃的表面修饰及其细胞相容性  

Surface modification of bioactive glass and the preliminary study on the cell biocompatibility

作　　者：卢玲[1] 游文玮[1] 王迎军[2] 赵营刚[2] 陈晓峰[2] 

机构地区：[1]南方医科大学药学院,广州510515 [2]华南理工大学生物医学工程研究院,广州510640

出　　处：《复合材料学报》2011年第1期114-118,共5页Acta Materiae Compositae Sinica

基　　金：国家自然科学基金(50472054);国家973项目(2005CB623902);广东省自然科学基金(04300428);中国博士后科学基金(2003033035)

摘　　要：采用硅烷偶联剂对生物活性玻璃(BG)进行表面修饰以改善其与高分子的亲和性。通过溶胶凝胶法制得BG,将氨丙基三乙氧基硅烷(APTES)键连到BG表面,采用FTIR、TG、激光粒度仪等对修饰前后的BG进行表征,并通过细胞实验对材料的细胞相容性进行初步研究。结果表明,修饰后BG的FTIR图谱上出现归属于C—H的伸缩振动吸收峰,在DTG曲线上观察到明显的有机基团燃烧失重峰,表明APTES接枝到生物玻璃表面;而MC-3T3细胞增殖测定和SEM结果显示经表面修饰后的BG更有利于细胞的生长增殖。The silane coupling agent was used to modify the inorganic bioactive glass（BG） surface aiming at improving affinity with polymer.BG was prepared by sol-gel method,then 3-aminopropyltriethoxysilane（APTES） was grafted onto BG surface.FTIR,TG and laser particle size analyzer were adopted to characterize BG before and after modification,and the cell biocompatibility of the material was studied preliminarily through cell culture.The results show that stretching vibration attributed to saturated C—H appears in FTIR spectrum of modified BG,and remarkable mass loss resulted from combustion of organic group is observed in DTG curve,which suggest that APTES has been bonded onto BG surface.The MC-3T3 cell proliferation measurement and SEM photos show that the modified BG is in favor of the cell growth and proliferation compared with unmodified BG.

关 键 词：生物活性玻璃 硅烷偶联剂 修饰 表面 细胞相容性 

分 类 号：R318.08[医药卫生—生物医学工程] TB332[医药卫生—基础医学]