脑卒中患者合并革兰阴性杆菌肺炎的耐药性调查  

Antimicrobial resistance of gram-negative bacilli causing pneumonia in stroke ptients

作　　者：王顺 王永涛 贾征夫 

机构地区：[1]武汉市第一人民医院检验科,湖北武汉430022

出　　处：《中华医院感染学杂志》2011年第6期1252-1253,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨脑卒中患者合并革兰阴性杆菌肺炎的耐药现状,为临床控制医院感染提供科学的试验依据。方法细菌鉴定按照《全国临床检验操作规程》,采用常规方法进行;药敏试验采用K-B法,结果依据CLSI2008-2009年规则的折点判读。结果 214例脑卒中患者合并革兰阴性杆菌肺炎的主要病原菌依次为铜绿假单胞菌(22.6%)、肺炎克雷伯菌(20.0%)、鲍氏不动杆菌(17.8%)、大肠埃希菌(11.8%);铜绿假单胞菌和鲍氏不动杆菌已出现了泛耐药菌株,分别为19.2%、22.0%。结论脑卒中患者合并革兰阴性杆菌肺炎的耐药性已十分严重,应采取综合性干预措施,预防与控制多药耐药细菌医院感染的发生与流行。OBJECTIVE To investigate the antimicrobial resistance in gram negative bacillus in stroke patients and to provide the experimental evidence for clinical controlling of nosocomial infections.METHODS Referring to National Guide to Clinical Laboratory Operation Procedures,the strains were identified by the routine methods.The antibiotic susceptibility testing was performed by K-B method and the results were assessed according to CLSI2008-2009.RESULTS Among 214 cases of stroke patients with Gram negative pneumonia,the main pathogens of Gam negative bacillus in stroke patients were Pseudomonas aeruginosa（22.6%）,Klebsiella pneunmoniae（20.0%）,Acinetobacter baumanii（17.8%）,Escherichia coli（11.8%）.The pan-drug resistant P.aeruginosa（19.2%） and A.baumannii（22.0%） were detected.CONCLUSION Antimicrobial resistance of Gram negative bacillus causing pneumonia in stroke patients is very serious.It should take comprehensive intervention measures to prevent and control the occurrence and prevalence of multi-drug resistant strains.

关 键 词：脑卒中 革兰阴性杆菌 肺炎 病原菌 抗药性 

分 类 号：R378[医药卫生—病原生物学]