儿童尿路感染常见病原菌的分布及耐药性  

Distribution of common pathogens from children with urinary tract infection and antimicrobial resistance

作　　者：胡红兵[1] 夏维[1] 

机构地区：[1]武汉市儿童医院检验部,湖北武汉430016

出　　处：《中华医院感染学杂志》2011年第6期1263-1264,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨儿童尿路感染常见病原菌的种类分布及耐药现状,为临床医师抗感染治疗提供参考依据。方法对医院2006年1月-2009年12月尿液标本分离的病原菌进行统计分析;细菌培养和菌株鉴定严格按《全国临床检验操作规程》进行;药敏试验采用纸片扩散法,药敏结果按照CLSI 2006-2009年标准进行分析判断。结果 3445份临床标本中,共分离出557株病原菌,病原菌检出率为16.2%;尿路感染病原菌以大肠埃希菌为主,占36.3%;除碳青霉烯类抗菌药物对大肠埃希菌和肺炎克雷伯菌,糖肽类抗菌药物对肠球菌属保持100.0%的抗菌活性以外,儿童尿路感染病原菌对多数常用抗菌药物均显示了较高的耐药性。结论儿童尿路感染病原菌的耐药性呈上升趋势,其原因与临床大量无序的使用广谱抗菌药物密切相关。OBJECTIVE To approach the distribution and antimicrobial resistance of pathogenic bacteria in urinary tract infecion in children,to provide the evidence of anti-infection treatment for the clinician.METHODS The strains isolates from urine specimen from Jan.2006 to Dec.2009 were included in this study.The positive results of urine culture were analyzed statistically.Referring to National Guide to Clinical Laboratory Procedures,the strains were cultured and identified.The susceptibility testing was performed by disc diffusion method.The resistance results were assessed according to CLSI 2006-2009 breakpoints.RESULTS The detection rate of the pathogens was 16.2%.The majority was Escherichia coli which accounted for 36.3%.Except for E.coli and Klebsiella peumoniae were 100.0% sensitive to carbapenems to and Enterococci were 100.0% sensitive to glycopeptides,the pathogenic bacteria in children with urinary tract infection were highly resistant to the most of the commonly used antibiotics.CONCLUSION The drug resistance of the pathogens causing urinary tract infection keeps an increasing tendency,which is closely related to the clinical abuse of broad spectrum antibiotics.

关 键 词：儿童 尿路感染 病原菌 分布 耐药性 

分 类 号：R378[医药卫生—病原生物学]