人工硒酶设计新策略  

New strategies for the design of artificial selenoenzymes

作　　者：尹艳镇 王亮[1] 张伟 徐家云 刘俊秋[1] 沈家骢[1] 

机构地区：[1]超分子结构与材料国家重点实验室吉林大学,长春130012

出　　处：《中国科学：化学》2011年第2期205-215,共11页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金项目(91027023;20874036;20921003);国家杰出青年基金(20725415);国家科技部973项目(2007CB808006);111计划(B06009)的资助

摘　　要：作为人体内重要的抗氧化酶,谷胱甘肽过氧化物酶受到人们越来越多的关注.为探索其催化机制,并开发极具潜力的抗氧化药物,国际上广泛开展了人工模拟谷胱甘肽过氧化物酶的研究工作.基于化学、生物学、超分子科学以及纳米科学及其深度交叉,人们研究构建了从小分子到大分子,再到纳米等不同结构的谷胱甘肽过氧化物酶模拟物.本文主要综述本研究组和其他研究组基于以大分子为骨架设计人工谷胱甘肽过氧化物酶的研究思路和策略.研究体系包括合成的大分子硒酶模型、自组装大分子硒酶模型和生物大分子硒酶模型等.As one of the antioxidative enzymes exerting important biological roles in living bodies,the selenoenzyme glutathione peroxidase has received increased attentions.Over the past decades,much effort has been paid to mimic the catalytic behavior of glutathione peroxidase for exploring the enzymatic catalytic mechanisms and for developing potential antioxidative medicines.A great number of artificial GPxs,ranging from small molecular GPx mimics to macromolecular ones,and to nanoenzymes have been designed and prepared based on chemical,biological and supramolecular strategies.In this article,we specify the ideas and strategies for developing artificial GPxs based on macromolecules as scaffolds.The artificial system contains synthesized macromolecule-based selenoenzymes,self-assembled selenoenzymes,biomacromolecule-based selenoenzymes and so on.

关 键 词：大分子 人工酶 硒酶 超分子化学 生物工程 

分 类 号：Q814[生物学—生物工程]