冠心爽合剂治疗不稳定性心绞痛的疗效及作用机制  

Effect of Guanxinshuang Mixture on Unstable Angina Pectoris and Its Mechanism

作　　者：周小明[1] 刘如秀[1] 李敏[1] 阚杰[1] 

机构地区：[1]中国中医科学院广安门医院心内科,北京市宣武区北线阁5号100053

出　　处：《中医杂志》2011年第6期479-482,共4页Journal of Traditional Chinese Medicine

基　　金：国家"十一五"科技支撑计划资助项目(2007BAI10B01-093)

摘　　要：目的观察冠心爽合剂治疗不稳定性心绞痛的疗效并探讨其作用机制。方法将56例患者随机分为对照组和治疗组各28例。对照组给予阿司匹林肠溶片、单硝酸异山梨酯片和低分子量肝素钙注射液治疗,治疗组在上述治疗基础上加服冠心爽合剂。两组疗程均为1个月。观察两组患者单项症状、心绞痛及西雅图心绞痛量表(SAQ)评分并检测血清生物标记物。结果治疗组可明显改善患者胸痛、胸闷、气短、腰膝酸软、头晕耳鸣症状,缩短心绞痛持续时间,减少硝酸甘油用量,增加SAQ评分(P<0.05或P<0.01)。治疗后,两组血清超敏C反应蛋白(hs-CRP)均有显著降低,但治疗组降低幅度更大(P<0.05);对照组基质金属蛋白酶9(MMP-9)、金属蛋白酶组织抑制剂1(TIMP-1)均无明显变化,治疗组MMP-9明显降低(P<0.05),而TIMP-1无明显变化。结论冠心爽合剂是治疗不稳定性心绞痛的有效中药复方,抗炎、稳定动脉斑块可能是其作用机制。Objective To observe the effect of Guanxinshuang Mixture（herbal mixture for coronary heart disease）on unstable angina pectoris and to explore its possible mechanism.Methods Fifty-six unstable angina pectoris patients were randomized into control group and treatment group,28 in each.The control group was given aspirin enteric-coated tablets,isosorbide mononitrate tablets and low molecular heparin,based on which,the treatment group was given Guanxinshuang Mixture as well.The treatment course was one month.Single symptom,angina pectoris and score of Seattle Angina Questionare were observed and the serum bioindicator was determined.Results The treatment group was significantly improved in relieving chest pain,chest fullness,shortness of breath,weakness and soreness in waist and knee,dizziness,and tinnitus;shortening the duration of angina pectoris,reducing the dose of nitroglycerin,and increasing SAQ score（P0.05 or P0.01）.After treatment,the hypersensitivity C reactive protein（hs-CRP）of the two groups was significantly lowered,and the lowering in the treatment group was more significant than in the control group（P0.05）.In the control group,the matrix metalloproteinase-9（MMP-9）and the tissue inhibitor of metalloproteinase-1（TIMP-1）were not changed significantly,while in the treatment group,MMP-9 was reduced（P0.05）but TIMP-1 was not changed significantly.Conclusion Guanxinshuang Mixture is effective in treating unstable angina pectoris.The mechanism is possibly owing to its anti-inflammation and stabilization of atherosclerotic plaques.

关 键 词：冠心爽合剂 不稳定性心绞痛 血清超敏C反应蛋白 基质金属蛋白酶9 金属蛋白酶组织抑制剂1 

分 类 号：R259[医药卫生—中西医结合]