血管紧张素Ⅱ-Ⅰ型受体自身抗体水平与子痫前期的关系  

Relationship between the role of serum angiotensin Ⅱ receptor subtype Ⅰ autoantibody and preeclampsia

作　　者：牛建清[1] 赵慧芳[1] 张秀兰 李宏芬[3] 陈宝丽[4] 范淑英[1] 高义军[1] 曾蕊[1] 刘耘[1] 

机构地区：[1]河北联合大学附属开滦医院妇产科,河北唐山063000 [2]河北省张北县医院妇产科,河北张北076450 [3]河北联合大学附属开滦医院检验科,河北唐山063000 [4]河北联合大学附属唐山妇幼保健院妇产科,河北唐山063000

出　　处：《中国实用妇科与产科杂志》2011年第3期195-198,共4页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的探讨血清中血管紧张素Ⅱ-Ⅰ型受体自身抗体水平与子痫前期的关系。方法选择2008年4月至2009年9月在河北唐山开滦医院、唐山妇幼保健院、张家口市张北县医院产科住院分娩的141例子痫前期患者作为病例组,选择同期114例正常妊娠妇女作为对照组,用ELISA法检测两组孕妇血清中血管紧张素Ⅱ-Ⅰ型受体自身抗体的水平,比较组间患者的一般情况,对子痫前期的危险因素进行单因素和多因素logistic回归分析。结果 (1)子痫前期患者的血管紧张素Ⅱ-Ⅰ型受体自身抗体水平高于对照组,差异有统计学意义(P<0.05)。子痫前期组年龄、高血压家族史、体质指数、腹围、低密度脂蛋白、甘油三酯水平均高于对照组,而受教育程度、经济收入水平低于对照组,差异有统计学意义(P<0.05)。(2)重度子痫前期组的血管紧张素Ⅱ-Ⅰ型受体自身抗体水平高于轻度子痫前期组,差异有统计学意义(P<0.05)。(3)多因素logistic回归分析结果显示:血管紧张素Ⅱ-Ⅰ型受体自身抗体、低密度脂蛋白、甘油三酯、空腹血糖是子痫前期独立的危险因素,OR值分别为3.397、2.201、4.167、1.638。结论 (1)血清中血管紧张素Ⅱ-Ⅰ型受体自身抗体水平增加是子痫前期的危险因素。(2)子痫前期患者有心血管疾病危险因素聚集现象。Objective To investigate the relationship between the role of serum AT1-AA and preeelampsia. Methods 141 pregnancy women with preeclampsia in Tangshan Kailuan hospital,Tangshan maternal and child health hospital and Zhangbei county hospital between April 2008 and September 2009 were enrolled in the case group,the control group included 114 normal pregnant women during the same period. Serum levels of AT1-AA were determined by ELISA and clinical data were compared between case and control groups. In the mean time, logistic regression was used to analyze the risk factors of preeclampsia. Results （ 1 ） The serum level of AT1-AA and patients age,high blood pressure family history,antepartum body mass index, abdomen cireumference, LDL-C and TG of preeclampsia were significantly higher than that in eontrol women,The family income and educational level were lower in preeclampsia group compared with control women. （2） The serum level of AT1-AA of severe preeelampsia group were significantly higher than the mild preeelampsia group. （3） Multiple logistic regression analysis showed that AT1-AA, LDL-C,TG and FBG were higher risk factors associated with the preeclampsia, the odds ratio were 3. 397,2. 201,4. 167,1. 638 respectively. Conclusion （ 1 ） The elevated level of serum AT1-AA might increase the risk of precclampsia. （2） The risk factors of cardiovascular disease were concentrated in preeelampsia.

关 键 词：子痫前期 血管紧张素Ⅱ-I型受体自身抗体 危险因素 

分 类 号：R71[医药卫生—妇产科学]