原发性胆汁性肝硬化患者46例抗着丝点抗体临床检测分析  

Detecion of clinical characteristics in 46 patients with primary biliary cirrhosis

作　　者：张爱兵[1] 

机构地区：[1]北京市房山区妇幼保健院,北京102488

出　　处：《中国医药导报》2011年第8期20-22,共3页China Medical Herald

摘　　要：目的:研究在原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)患者中,抗着丝点抗体(anticentromere anti-body,ACA)与临床表现之间的关系。方法:用间接免疫荧光法检测PBC患者血清抗核抗体(ANA)各荧光模式,比较ACA阳性和阴性患者临床表现的差别和免疫学指标的差别。结果:156例PBC患者中ACA阳性46例(25%),ACA阳性组乏力、黄疸症状少于ACA阴性组,两组间有统计学差异(P<0.05),肝功能异常症状两组间差异有统计学意义(P<0.05),ACA阳性组多于ACA阴性组。免疫学指标中,CD4+和IgM在两组间有统计学意义,ACA阳性组高于阴性组(P<0.05)。结论:ACA阳性的PBC患者临床表现隐匿,以单纯肝功能异常多见,易造成临床上漏诊。Objective： To investige the clinical relationship of anticentromere antibody （ACA） in patients with primary biliary cirrhosis （PBC）. Methods： ACA was detected using indirect immunofluorescence （IIF） in 156 patients with PBC, and the difference was compared between the ACA positive and negative gyoup. Results： 46 of the 156 eases in primary biliary cirrhosis were positive, the sensibility was 29%. ACA positive group fatigue, icteric symptoms ACA negative groups, less than there were significant differences between the two groups （P〈0.05）, liver function is abnormal symptoms between the two groups was statistically significant （P〈O.05）, ACA positive group than ACA negative groups. Immunological indexes, CD4＋ and IgM between the two groups was statistically significant positive group, ACA-positive group was higher than negative group （P〈0.05）. Conclusion： The symptoms of positive of ACA is dormancy, and with a simple liver function ab- normalities more common, it easily lead to clinical misdiagnosis.

关 键 词：肝硬化 胆汁性 抗着丝点抗体 

分 类 号：R593.2[医药卫生—内科学]