宫内发育迟缓对胰腺β细胞发育和功能影响机制的研究进展  

Progress on the relationship of pancreatic cells development and function and intrauterine growth retardation

作　　者：李瑶(综述)[1] 辛颖[2] 李书琴(审校)[2] 

机构地区：[1]沈阳市儿童医院内科,110032 [2]中国医科大学附属盛京医院儿科,沈阳110004

出　　处：《国际儿科学杂志》2011年第2期124-126,共3页International Journal of Pediatrics

摘　　要：研究表明，宫内发育迟缓儿发生胰岛素抵抗综合征的危险性大大增加。动物模型研究证实，宫内发育迟缓个体内调节胰腺β细胞发育的因子及调控糖脂代谢的酶类、蛋白以及胰岛素信号传导分子表达下降，造成胰腺β细胞数目减少，增殖能力下降，凋亡增加，胰岛素分泌减少，胰岛素敏感性降低，外周组织摄取葡萄糖的能力下降，出现糖代谢和脂肪酸代谢异常，导致高血糖和高血脂，产生胰岛素抵抗。Intrauterine growth retardation （IUGR） can improve the danger of insulin resistance syndrome. It was reported that regulatory factors of βcells development and enzymes of regulating metabolism of glucose, fat, insulin signal transduction and effectcr molecule were expressed at a low level in the IUGR. As a result, the number of βcells, proliferation, insulin secretion and insulin sensitivity was reduced, apoptosis was increased, and glucose intake in peripheral tissue declined. All these factors contribute to the insulin resistance syndrome.

关 键 词：宫内发育迟缓 胰腺 动物模型 胰岛素抵抗 

分 类 号：R714.7[医药卫生—妇产科学]