p300／CBP相关因子的生物特性及其与疾病的关系  

The biological characteristics of p300/CBP-associated factor and relationship with disease

作　　者：谢靖芸(综述)[1] 田杰[1] 朱静(审校)[2] 

机构地区：[1]重庆医科大学附属儿童医院心内科,400014 [2]重庆医科大学附属儿童医院儿研所,400014

出　　处：《国际儿科学杂志》2011年第2期139-141,共3页International Journal of Pediatrics

摘　　要：p300／CBP相关因子（p300／CBP—associated factor，PCAF）是真核细胞内一种重要的组蛋白乙酰转移酶。PCAF除了能乙酰化组蛋白，还能乙酰化非组蛋白。PCAF参与细胞内多种生物学过程，并参与病毒与细胞的相互作用。PCAF失衡可导致多种器官的发育异常，且与某些肿瘤的发生发展相关。p300/CBP-associated factor （PCAF）is an important histone acetyhransferase in eukaryotic cells. PCAF can acetylizes histone and non-histone. PCAF participates in various biological processes of cells and in the interaction between virus and cells. The imbalance of PCAF would lead to abnormal development of various organs, and related to the development of some tumors.

关 键 词：p300/CBP相关因子 组蛋白乙酰化酶 组蛋白修饰 

分 类 号：R587.1[医药卫生—内分泌]