阻塞性睡眠呼吸暂停低通气综合征白天嗜睡机制的研究现状  

Excessive daytime sleepiness in obstructive sleep apnea-hypopnea syndrome- - an update

作　　者：黄鸿波[1] 庄锡彬[1] 

机构地区：[1]福建医科大学附属泉州市第一医院呼吸内科,362000

出　　处：《国际呼吸杂志》2011年第5期382-384,共3页International Journal of Respiration

摘　　要：白天嗜睡是阻塞性睡眠呼吸暂停低通气综合征（OSAHS）特征性的症状之一，其危害性大。白天嗜睡最主要的评价方法是Epworth嗜睡量表和多次睡眠潜伏期试验。OSAHS患者白天嗜睡的发生机制未明，但可能主要与睡眠片段化、夜间缺氧、肿瘤坏死因子及P物质等因素有关。Excessive daytime sleepiness（EDS） is commonly considered to be a cardinal sign of obstructive sleep apnea-hypopnea syndrome （OSAHS）. It constitutes a major health hazard. EDS is commonly assessed using the Epworth sleepiness scale and the multiple sleep latency test. The mechanism of EDS in patients with OSAHS is unclear. From this update, we concluded that EDS seen in OSAHS patients might be associated with various pathophysiologic mechanisms, including sleep fragmentation, nocturnal hypoxaemia, tumor necrosis factor levels, and substance P levels.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 白天嗜睡 睡眠片段化 肿瘤坏死因子 P物质 

分 类 号：R766[医药卫生—耳鼻咽喉科]