电热原子吸收光谱法测定奥沙利铂中的铅和砷  

Determination of Lead and Arsenic in Oxaliplatin by Electrothermal Atomic Absorption Spectrometry

作　　者：熊敏[1] 普绍平 刘春侠[1] 贺与平[1] 何素芳[1] 单云[1] 

机构地区：[1]昆明理工大学分析测试研究中心,昆明市学府路253号650093 [2]昆明贵研药业有限公司,昆明市650106

出　　处：《光谱实验室》2011年第2期640-644,共5页Chinese Journal of Spectroscopy Laboratory

基　　金：云南省级科研院所技术开发专项课题(2002KFZX-30)

摘　　要：采用电热原子吸收光谱法测定抗肿瘤新药奥沙利铂中的痕量铅和砷,实验优选了灰化、原子化的最佳温度条件,进行了加标回收实验和精密度实验,加标回收率铅在97.88%—103.96%之间,砷在92.12%—105.72%之间。奥沙利铂是含贵金属的原料药,价格昂贵,检测时不耗费大量的样品、降低成本很重要。本法取样量少,不需要高温灰化和繁琐的样品富集和前处理技术,简单的酸溶解处理配成溶液后,即可直接上机测定,试样中的有机成分在灰化阶段可被除去。The trace levels of lead and arsenic in anti-cancer drug oxaliplatin were determined by electrothermal atomic absorption spectrometry.In the method,the best ashing and atomization conditions were optimized.Since the oxaliplatin was a kind of raw material medicine had precious metals and very expensive.It was important to reduce the cost of the determination and the amount of samples was needed without high-temperature ashing and the tedious sample pretreatment technology.The samples were dissolved by nitric acid and directly used for determination.The organic component could be destroyed at the ashing stage.The recoveries of lead were 97.88%—103.96%,and that of arsenic were 92.12%—105.72%.

关 键 词：奥沙利铂 铅 砷 电热原子吸收光谱法 

分 类 号：O657.31[理学—分析化学]