波赛链霉菌合成蒽环类抗肿瘤抗生素研究进展  

Advances on biosynthesis of anthracycline antibiotics by Streptomyces peucetius

作　　者：贺建武[1] 陈奇辉[1] 刘祝祥[1] 庄大春[1] 黄苛[1] 陈义光[1] 

机构地区：[1]植物资源保护与利用湖南省高校重点实验室吉首大学生物资源与环境科学学院,吉首416000

出　　处：《中国抗生素杂志》2011年第3期161-164,196,共5页Chinese Journal of Antibiotics

基　　金：国家自然科学基金项目(NO.30970007);湖南省重点学科建设项目(NO.JSS2009Z01);吉首大学研究生科研创新项目(NO.JGY201018)

摘　　要：蒽环类抗生素(anthracyclines antibiotic)在治疗急性非淋巴细胞性白血病、恶性淋巴瘤、肉瘤、乳腺癌等方面有着很好的疗效,成为临床首选药物。波赛链霉菌(Streptomyces peucetius)是合成柔红霉素、多柔比星、表阿霉素、表柔红霉素、洋红霉素、13-脱氧洋红霉素等多种蒽环类抗肿瘤抗生素的最重要菌株。该菌产生的生物活性物质及其合成途径成为国内外的研究热点。本文综述了近年来波赛链霉菌合成蒽环类抗肿瘤抗生素的研究进展,并展望其发展前景。Anthracyclines antibiotics have been a preferred clinical drug, attributable to their ability to exhibit good effectiveness in the treatment of a number of cancers, such as acute nonlymphocytic leukemia, malignant lymphoma, sarcoma and breast cancer. Streptomyces peucetius is the best important species synthesizing anthracycline antibiotics （daunorubicin, doxorubicin, 4＇-pei-doxorubicin, 4＇-pei-daunorubicin, carminomycin, 13- deoxocarminomycin, etc.）. Studies on the biosynthesis and pathway engineering of bioactive products by S. peucetius has been a hot point at home and abroad. The research advances on the biosynthesis of anthracyclines antibiotics by S. peucetius were summarized, and the development trend was also pointed out in this paper.

关 键 词：波赛链霉菌(Streptomyces peucetius) 蒽环类抗肿瘤抗生素 生物合成 途径工程 

分 类 号：R979.14[医药卫生—药品]