金银花化学成分研究  

Study on Chemical Constituents of Lonicerae Japonicae Flos

作　　者：冯卫生[1] 陈欣[1] 郑晓珂[2] 张春磊[1] 李丹丹[1] 

机构地区：[1]河南中医学院药学院,郑州450008 [2]河南中医学院基础医学院,郑州450008

出　　处：《中国药学杂志》2011年第5期338-340,共3页Chinese Pharmaceutical Journal

摘　　要：目的研究金银花（Lonicerae Japonicaer Flos）化学成分。方法利用Diaion HP-20,Toyopearl HW-40,硅胶柱等柱色谱技术进行分离纯化,根据化合物的理化性质和光谱数据鉴定结构。结果分离并鉴定了11个化合物的结构：对羟基苯酚（Ⅰ）,1,2,4-苯三酚（Ⅱ）,原儿茶酸（Ⅲ）,3-（3,4-二羟基苯基）丙酸（Ⅳ）,4-羟基桂皮酸（Ⅴ）,4-羟基桂皮酸甲酯（Ⅵ）,咖啡酸甲酯（Ⅶ）,芹菜素（Ⅷ）,3′-甲氧基木犀草素（Ⅸ）,5,3′-二甲氧基木犀草素（Ⅹ）,木犀草素-5-O-β-D-葡萄糖苷（Ⅺ）。结论化合物Ⅰ~Ⅺ均为首次从该植物中分离得到。OBJECTIVE To study the chemical constituents of Lonicerae Japonicaer Flos.METHODS The compounds were isolated and purified by Diaion HP-20,Toyopearl HW-40,and silica gel column chromatography.The structures were identified on the basis of spectral data and physiochemical properties.RESULTS Eleven compounds were isolated and identified as： p-hydroxy-phenol（Ⅰ）,1,2,4-benzenetri（Ⅱ）,protocatechuic acid（Ⅲ）,3-（3,4-dihydroxyphenyl） propionic acid（Ⅳ）,4-hydroxy cinnamie acid（Ⅴ）,4-hydroxy cinnamie acid methyl（Ⅵ）,caffeic acid methyl ester（Ⅶ）,apigenin（Ⅷ）,3′-methoxy luteolin（Ⅸ）,5,3′-dimethoxy luteolin（Ⅹ）,luteolin-5-O-β-D-glucopyranoside（Ⅺ）.CONCLUSION CompoundsⅠ-Ⅺ were isolated from this plant for the first time.

关 键 词：金银花 化学成分 结构鉴定 

分 类 号：R284[医药卫生—中药学]