矮桃化学成分研究  

Chemical Constituents of Lysimachia clethroides Duby

作　　者：岳淑梅[1] 陈百泉[1] 苑鹏飞[1] 崔维恒[1] 康文艺[1] 

机构地区：[1]河南大学中药研究所,河南开封475004

出　　处：《中国药学杂志》2011年第5期341-343,共3页Chinese Pharmaceutical Journal

基　　金：河南大学大学生创新性实验计划(09NB026)

摘　　要：目的研究矮桃（Lysimachia clethroidesDuby）化学成分。方法采用各种色谱法分离,运用多种波谱技术鉴定结构。结果从醋酸乙酯和甲醇部位分离鉴定了7个化合物：α-香树酯醇（1）,β-香树酯醇（2）,β-谷甾醇（3）,豆甾-5,22（E）-二烯-3β-醇（4）,12-乌苏酸-3-O-β-D-葡萄糖苷（5）,12-乌苏烷-3-O-β-D-葡萄糖苷（6）和β-胡萝卜苷（7）。结论化合物1~3、5和6均为首次从该植物中分离得到,化合物1、5和6为首次从该属中分离得到。OBJECTIVE To study the chemical constituents of Lysimachia clethroides Duby.METHODS Compounds were isolated by column chromatographic techniques and their structures were elucidated by a combination of EI-MS and NMR spectroscopy.RESULTS Seven compounds were isolated from the ethyl acetate and methanol extracts,and identified as α-amyrin（1）,β-amyrin（2）,β-sitosterol（3）,stigmaster-5,22（E）-dien-3β-ol（4）,12-urosolic acid-3-O-β-D-glucoside（5）,12-ursen-3-O-β-D-glucopyranoside（6） and β-daucosterol（7）.CONCLUSION Compounds 1-3,5 and 6 were isolated for the first time from this plant.Compound 1,5 and 6 were isolated for the first time from this genus.

关 键 词：矮桃 12-乌苏酸-3-O-β-D-葡萄糖苷 12-乌苏烷-3-O-β-D-葡萄糖苷 β-胡萝卜苷 化学成分 

分 类 号：R284.1[医药卫生—中药学]