Pictet-Spengler酶及其相关生物学特性  

Pictet-Spenglerases and their Related Biologyical Characteristics

作　　者：陈薛钗[1] 王睿[1] Abida Arshad 邓玉林[1] 

机构地区：[1]北京理工大学生命学院,北京100081

出　　处：《化学通报》2011年第3期218-224,共7页Chemistry

基　　金：国家自然科学基金项目(20435020)资助

摘　　要：Pictet-Spengler(P-S)反应在合成异喹啉和β-咔啉衍生物的过程中起着重要作用,它作为多种生物碱合成过程中最基础的一步反应,近年来受到人们广泛的关注。在新形成的杂环体系中,P-S反应催化醛基碳原子形成为新的手性中心。简单P-S反应得到的是外消旋混合物,但具有重要生物活性的物质通常具有立体专一性,因此寻找能催化不对称P-S反应的催化剂已成为该领域的研究热点。"Pictet-Spenglerases"是指催化P-S反应的酶的总称,它能催化产生高立体化学纯度的产物。由酶催化的P-S反应在自然界中很少,至今只有少数几种酶得到纯化和鉴定。基于此,本文从P-S反应出发,综述了近年来分离鉴定得到的Pictet-Spengler酶及其相关的生物学特性,以期为将来该类新酶的发现及系统研究提供借鉴。Pictet-Spengler（P-S） reaction plays an important role in the synthesis of isoquinoline and β-carboline derivatives.Being one of the most basic-steps in the syntheses of many alkaloids,it has attracted much attention in recent years.During P-S reaction,the original aldehyde carbon atoms become a new chiral center in the newly formed heterocyclic system.The products of simple P-S are racemic mixture,so searching catalyst for asymmetric reaction has been one of the hot topics.＂Pictet-Spenglerases＂which may generate products with high stereochemical purity,refer to the enzymes that catalyze P-S reactions.The enzymes which can catalyze P-S reactionsare rare in nature and only a few of them had been purified and identified so far.Some recent isolated enzymes and their related biological characteristics are reviewed for providing some assistance to find new enzymes and research systems in this field.

关 键 词：Pictet-Spengler酶 Pictet-Spengler反应 酶 生物合成 特性 

分 类 号：O621.2[理学—有机化学]