微波干燥对舒胸片方提取物有效成分的影响及传质模型的研究  

Effective constituents and kinetic model of microwave drying from Shuxiong prescription

作　　者：张萍[1] 廖正根[1] 梁新丽[1] 赵国巍[1] 赖珺[2] 祝婧[1] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,江西南昌330004 [2]赣州市人民医院药剂科,江西赣州341000

出　　处：《中国中药杂志》2011年第5期563-568,共6页China Journal of Chinese Materia Medica

基　　金：国家"十一五"科技支撑计划项目(2006BAIO9B07-05);江西省卫生厅中医药科研基金项目(2007A018);江西省教育厅科学技术研究项目(GJJ08327);中药新型给药系统技术平台(2009ZX09310-005)

摘　　要：目的:考察微波干燥对舒胸片方提取物有效成分的影响及传质模型的研究。方法:研究了不同微波功率及物料装载量等因素对舒胸片方中有效成分阿魏酸及羟基红花黄色素A的干燥转移率的影响;根据Fick第二定律,采用Origin 7.5软件对动力学模型进行回归分析,建立舒胸片方提取物微波干燥过程的薄层干燥动力学方程。结果:增加微波功率或装载量对有效成分均有一定的损失作用;舒胸片方提取物微波干燥过程符合Logarithmic模型,在真空微波干燥条件下的有效扩散系数Deff随微波强度的增加而增加,随装载量的增加而降低;并由有效扩散系数确定了舒胸片方提取物活化能为125.80 W.g-1。结论:通过建立干燥过程传质模型,对进一步改善产品的质量,提高干燥效率都具有重要的意义。A mathematical model of microwave drying kinetics based on Fick＇s second diffusion law was established and and the influence of microwave drying on ferulic acid（FA） and hydrosafflower yellow A（HSYA） in Shuxiong prescription was studied.The proposed model has been verified by using experimental data from microwave drying of Shuxiong prescription.By increasing the microwave output power（500-650 W） and the sample amount（15-60 g）,the diversion rate of FA and HSYA changed.In order to determine the kinetic parameters,the drying data were fifed to various models based on the ratios of differences between the initial and final moisture contents and equilibrium moisture content versus drying time.The activation energy was calculated using an exponential expression based on Arrhenius equation.The relationship between the drying rate constant and effective moisture diffusivity was also estimated,and it showed linear.

关 键 词：微波干燥 动力学模型 舒胸片方提取物 转移率 

分 类 号：R286.0[医药卫生—中药学]