肝纤维化病理分期与肝血流动力学、肝纤维化指标的关系  

Relationship between pathological stage and liver hemodynamics,hepatic fibrosis index in fibrosis patients

作　　者：黄菊芬[1] 周桦[1] 王贤明[1] 陈炫龙[1] 

机构地区：[1]郧阳医学院附属太和医院超声影像科,湖北十堰442000

出　　处：《中国现代医学杂志》2011年第2期212-215,共4页China Journal of Modern Medicine

摘　　要：目的探讨肝纤维化患者病理分期与肝血流动力学、肝纤维化指标的关系。方法 60例肝纤维化患者患者用彩超、放射免疫法及病理HE染色法进行检查,对肝纤维化患者不同病理分期与肝血流动力学、肝纤维化指标进行对比分析。结果肝纤维化S1、S2期肝门脉血流动力学参数与对照组无显著差异,在S3、S4期肝门脉血流动力学参数与正常组对照组比较有显著差异(P<0.01);且血清肝纤维化标志物HA、HPCⅢ和CIV含量明显高于正常对照组(P<0.05);肝纤维化患者病理分期与血清肝纤维化标志物呈正相关(r=0.5612,P<0.05)。结论肝纤维化患者病理分期与肝血流动力学,血清肝纤维化标志物有关。对肝纤维化的诊断及疗效观察有一定临床应用价值。[Objective] To approach the relationship between pathological stage and liver hemodynamics, liver fibrosis index in hepatic fibrosis patients. [Methods] 60 patients with hepartie fibrosis were detected by CDFI, radioimmunity and pathological HE staining, and the different pathologic stage and liver hemodynamies, liver fibrosis index were analyzed. [Results] In Sl, S, stage, no significant deviation was existed in portal vein hemodymamies parameters between experimental and control group, in $3, 54 stage, significant deviation was happened to control group （P〈0.01）. and in serum hepatic fibrosis marker HA, HPCIII and CIV content were higher than the control group obviousl （P〈0.05）; positive correlation was found between pathologic stage and hepatic fibrosis marker in serum （r=0.5612, P〈0.05）. [Conclusion] In hepatic fibrosis cases, pathologic stage was correlative with liver hemodynamics and fibrosis marker in serum, and it is of value in diagnosis of hepatic fibrosis and observation of curative effect.

关 键 词：肝纤维化 血流动力学 病理 

分 类 号：R445.1[医药卫生—影像医学与核医学]