穴位埋线对慢性心力衰竭大鼠血压与心功能的影响  

Influence of Acupoint-catgut-implantation on Blood Pressure and Cardiac Function in Chronic Congestive Heart Failure Rats

作　　者：邓元江[1] 梁伟雄[2] 程淑意[2] 

机构地区：[1]中山大学附属第一医院针灸科,广州510080 [2]广州中医药大学临床科研设计、衡量、评价中心,广州510405

出　　处：《针刺研究》2011年第1期40-45,共6页Acupuncture Research

基　　金：中国博士后科学基金(No.2005038175);教育部高等学校博士学科点基金(No.20050572008);广东省自然科学基金(No.06300042)

摘　　要：目的:探讨穴位埋线对慢性心力衰竭大鼠血压与心功能的干预作用。方法:将雌性SD大鼠随机分为假手术组、心衰模型组、穴位埋线组和卡托普利组,采用腹主动脉缩窄7周制作大鼠慢性心力衰竭模型。穴位埋线组采用"内关""心俞""足三里"埋线治疗2次,卡托普利组采用卡托普利混悬液每天灌胃1次。治疗7周后无创检测大鼠的血压、心率与左室射血分数(LVEF)。结果:①造模后14周,模型组的血压均明显高于假手术组(P<0.01),穴位埋线、卡托普利治疗7周后血压均明显降低(P<0.01)。②造模后14周,模型组心率有所增快(P<0.05),穴位埋线、卡托普利治疗后均可减慢大鼠的心率(P<0.01)。③造模后14周模型组LVEF明显低于假手术组(P<0.01),穴位埋线可提高大鼠的LVEF(P<0.05),增强左室射血功能,卡托普利的作用不明显(P>0.05)。结论:穴位埋线对压力超负荷所致慢性心力衰竭大鼠有降低血压、减缓心率、提高LVEF的作用,可缓解慢性心力衰竭。Objective To observe the effect of acupoint-catgut-implantation on blood pressure and cardiac function in chronic heart failure （CHF） rats. Methods A total of 60 SD female rats were randomly divided into sham-operation group （sham）, CHF model group, catgut-implantation group, Captopril group. CHF model was established by suprarenal abdominal artery constriction. Surgical catgut （No. 3-0, 2-3 mm length piece） was implanted into bilateral ＂Neiguan＂ （PC 6）, ＂Xinshu＂ （BL 15） and ＂Zusanli＂ （ST 36） twice for 7 weeks. Rats of the Captopril group were treated with intragastric infusion of Captopril from the 50^th day on after the operation, once daily for 7 weeks. Blood pressure （BP） including the systolic blood pressure （SBP）, diastolic blood pressure （DBP） and mean blood pressure （MBP）, heart rate （HR） and the left ventricular ejection fraction （LVEF） were detected respectively by cardiac sonography. Results On the 14^th week after modeling, in comparison with the sham group, the SBP, DBP, MBP and HR in rats of the model group were increased significantly （ P〈0.01, P〈0.05）, while LVEF of the model group was decreased considerably （P〈0.01）. Compared with the model group, the SBP, DBP, MBP and HR after 7 weeks＇ treatment in rats of the catgut-implantation and Captopril groups were decreased considerably （P〈0.01）, while the LVEF of the catgut-implantation group was increased evidently （P〈0.05）. No significant differences were found between the catgut-implantation and Captopril groups in the SBP, DBP, MBP and HR levels, and between the model and Captopril groups in LVEF values （P〉0.05）. Conclusion Acupoint-catgut-implantation can down-regulate BP and HR, and increase LVEF in chronic congestive heart failure rats, which may contribute to its effect in ameliorating the cardiac function.

关 键 词：慢性心力衰竭 穴位埋线 心脏功能 血压 左室射血分数 

分 类 号：R245.91[医药卫生—针灸推拿学]