慢性海洛因依赖患者前额叶皮质功能连接变化的fMRI研究  

The Altered Functional Connectivity of Prefrontal Cortex in Heroin Dependent Individuals：fMRI Study

作　　者：杨伟川[1] 王亚蓉[1] 李强[1] 李玮[1] 朱佳[1] 黄玉芳[1] 王玮[1] 

机构地区：[1]第四军医大学唐都医院放射科,陕西西安710038

出　　处：《实用放射学杂志》2011年第2期153-156,共4页Journal of Practical Radiology

基　　金：基金项目：国家自然科学基金资助项目（30870685,81071142,81071143）;陕西省科技厅攻关计划项目（2010K16-03-01,2010K16-03-02）;陕西省卫生厅资助项目（编号：2009K0165）.

摘　　要：目的通过分析慢性海洛因成瘾者认知抑制性控制环路的关键脑区一前额叶功能连接的变化，探讨其在成瘾中的作用。方法慢性海洛因依赖男性患者12例，与之年龄、受教育程度和尼古丁依赖水平匹配的健康被试12例参加本研究。采用3．0T磁共振扫描仪，8通道头线圈，对被试分别进行头颅结构和静息态功能磁共振扫描，后利用SPM8软件以双侧前额叶为感兴趣区，分别进行组内和组间前额叶静息态功能网络分析。结果与对照组比较，慢性海洛因依赖组前额叶与额眶回、角回、颞中回、双侧苍白球功能连接度显著上升，与前扣带回的功能连接显著下降（t=3．5，P〈0．001；连续体素显示个数〉5）。结论慢性海洛因依赖．者认知抑制性控制功能的神经环路受损，而奖赏以及动机驱动环路功能出现异常强化。Objective To investigate whether the functional connectivity of the brain region, prefrontal cortex {PFC}, which implicated in cognition and inhibitory control, changed in chronic heroin dependent individuals. Methods Twelve male chronic heroin users and 12 age-- , gender-- and nicotine dependence-- matched healthy subjects participated in the present study. The partici- pants received a resting state fMRI scan with a General Electric 3.0 Tesla scanner and a 8--channel birdcage head coil. Functional connectivity was analyzed based on resting state fMRI data in order to determine the temporal correlation between PFC and the other regions on the whole brain scale. Finally, one--sample t--test and two--sample t--test were applied to observe the change of func- tional connectivity of PFC between the two groups. Results The PFC of heroin group showed higher strength of functional connectivity between PFC and orbitofrontal cortex { OFC）, pallium, but lower between PFC and anterior cingulate cortex （ACC） in chronic heroin users than that in healthy subjects （t=3.5, P〈0. 001 ）. Conclusion Dysfunctional connectivity of PFC--OFC, PFC-- lentiform nucleus and PFC--ACC in drug users suggests abnormal functional organization related to motivation, reward and inhibitory control in addicted brain.

关 键 词：脑 海洛因 功能磁共振成像 

分 类 号：R996[医药卫生—毒理学] R742[医药卫生—药学]