阿托伐他汀治疗对肾脏衰老的影响  

The effects of atorvastatin on aging kidney

作　　者：赵佳慧[1] 程庆砾[1] 叶平[1] 

机构地区：[1]中国人民解放军总医院老年肾科,北京100853

出　　处：《中国应用生理学杂志》2011年第1期98-101,139,共5页Chinese Journal of Applied Physiology

基　　金：国家自然科学基金资助项目(70872713);解放军总医院苗圃基金资助项目(07MP40)

摘　　要：目的:观察长期应用不同剂量的阿托伐他汀对老年大鼠肾脏的影响。方法:正常20月龄Wistar雌性大鼠分为3组(n=9):①给予大剂量阿托伐他汀10 mg/(kg.d)灌胃;②给予小剂量阿托伐他汀1 mg/(kg.d)灌胃;③给予等剂量生理盐水灌胃,三组均连续灌胃4个月后处死大鼠,以3月龄大鼠(n=9)为对照。测定肾重指数,血清肌酐及血清脂蛋白,行PAS染色、天狼猩红染色观察肾脏病理,计算肾小球硬化指数。结果:三组老年大鼠的肾脏重量均显著减轻。老年大鼠小剂量阿托伐他汀组显著降低老年大鼠的血清肌酐(P<0.01)。老年大鼠血脂水平显著高于青年大鼠,大剂量阿托伐他汀组显著降低老年大鼠的总胆固醇(CH)和低密度脂蛋白胆固醇(LDL-C,P均<0.05),小剂量阿托伐他汀组显著降低老年大鼠的LDL-C(P<0.05)。大剂量阿托伐他汀组降低血脂的作用强于小剂量阿托伐他汀组。老年大鼠肾脏病理改变为显著的肾小球局灶节段性硬化,肾小球硬化指数显著增高(P<0.05),肾间质内大量炎性细胞浸润,肾内小动脉明显硬化。阿托伐他汀组显著减轻肾小球的局灶节段性硬化的程度,减少肾间质内炎性细胞浸润,显著改善肾内小动脉粥样硬化的病变程度。大剂量阿托伐他汀改善肾组织异常病理表现的作用更为明显。结论:长期应用阿托伐他汀可以显著改善老年大鼠肾脏衰老的异常病理改变,这些作用可能是通过阿托伐他汀的降脂作用、显著减轻肾内小动脉硬化及显著减少肾间质内炎性细胞浸润而综合起效的。Objective： To evaluate whether taking atorvastatin for long time has positive effects on age-related renal impairment.Me-thods： 20-month-age normal female Wistar rats were divided into three groups（n=9）.First group were fed atorvastatin 10 mg/（kg·d）.Second group were fed atorvastatin 1 mg/（kg·d）.Third group were fed the same volume normal saline served as control.All the rats were sacrificed after four months.3-month-age normal female Wistar rats（n=9） also served as normal control.Kidney weight,serum creatinine（Scr） and bloodlipoids were measured.Paraffin sections of renal tissues were stained with PAS and Sirius red.Sclerosis index of glomerulus was calculated.Results： Renal mass diminution was found in all the groups of aging rats.Scr was decreased in the group of aging rats with atorvastatin 1 mg/（kg·d）.The level of blood-lipoids of aging rats was higher than that of young rats.The level of serum cholesterol and low-density lipoprotein（LDL） were decreased in first group（both P0.05）and only LDL decreased in second group（P0.05）.Morphological changes of aging kidney were focal segmental glomerulosclerosis,widen of mesangial region,infiltration of inflammatory cells and sclerosis of arteriole.The treatment of atorvastatin improved the pathologic changes in the aging rats significantly,especially in the first group.Conclusion： Taking atorvastatin for long time can notably improve the pathological changes of aging kidney.All these effects may be induced by lowing of blood-lipoids,relieving the sclerosis of renal arteriole and reducing the infiltration of inflammatory cells.

关 键 词：老年 肾脏 阿托伐他汀 

分 类 号：R97[医药卫生—药品]