蓝斑核、中缝大核和迷走神经背核在胃运动调节中的关系  

The relationships among raphe magnus nucleus,locus coeruleus and dorsal motor nucleus of vagus inthe descending ragulation of gastric motility

作　　者：乔卉[1] 安书成[1] 徐畅[1] 

机构地区：[1]陕西师范大学生命科学学院,西安710062

出　　处：《中国应用生理学杂志》2011年第1期124-128,共5页Chinese Journal of Applied Physiology

摘　　要：目的:探讨蓝斑(LC)、中缝大核(NRM)和迷走神经背核(DMV),及其相关递质和受体对胃运动的调节途径及机制,阐明它们在调节胃运动中的相互关系。方法:实验采用了核团定位电刺激、损毁和核团微量注射等实验方法,以记录胃内压,统计胃收缩幅度作为胃运动变化的指标。结果:①刺激LC显著降低胃收缩幅度(P<0.01),损毁DMV可以减弱此效应,而阻断DMV上的肾上腺素能α受体,可以反转此抑胃效应。②刺激NRM显著降低胃收缩幅度(P<0.01),损毁DMV后此效应被消除;阻断DMV上的5-HT2A受体使胃收缩幅度大幅度降低(P<0.01),此时再刺激NRM不能进一步的抑制胃运动;而损毁LC后刺激NRM,可消除NRM的抑胃效应,在LC注射5-HT2A受体阻断剂也可以消除该效应。结论:①LC可能通过DMV的5-HT2A受体和α受体对生理条件下正常胃的运动起着重要的双向调节作用;②NRM通过LC上的5-HT2A受体而发挥其对胃运动的抑制效应。Objective： To explore the interrelationship among dorsal motor nucleus of the vagus（DMV）,locus coeruleus（LC） and raphe magnus nucleus（NRM） in the mechanism of the descending regulation on gastric motility,which may constitute a parasympathetic local circuit,work as a neural center of gastric modulation in brainstem.Methods： Using nucleus location,electric stimulation and lesion,together with microinjection,and recording the inter-gastric pressure.Results： ①LC stimulation could inhibit the gastric motility significantly（P0.01）,DMV lesion weaken this effect,while blocking the α receptor on DMV could reverse the effect.②NRM stimulation reduced the amplitude of gastric constriction（P0.01）,DMV lesion could abolish the effect,but blocking the 5-HT2A receptor on DMV depressed the gastric motility heavily（P0.01） like NRM stimulation.While LC lesion could abolish the effect of NRM stimulation,and microinjection of ritanserin into LC could likewise abolish it.Conclusion： ①LC inhibit the gastric motility via α receptor in DMV,and meanwhile may excite it through 5-HT2A receptor in DMV,these two ways work together to keeping the gastric motility amplitude normally.②NRM inhibit the gastric motility via 5-HT2A receptor in LC.

关 键 词：蓝斑核 中缝大核 迷走神经背核 胃运动 

分 类 号：Q41[生物学—生理学]