基于药效物质基础的中药药物代谢动力学  

Material Basis-based Pharmacokinetic Investigation of Chinese Medicine

作　　者：陈修平[1] 钟章锋[1] 徐曾涛[1] 燕茹[1] 李澎涛[2] 王一涛[1] 

机构地区：[1]澳门大学中华医药研究院,澳门999078 [2]北京中医药大学东直门医院,北京100700

出　　处：《世界科学技术-中医药现代化》2011年第1期137-142,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：澳门特别行政区科学技术发展基金(029/2007/A2)：中药抗肿瘤的系统药理学评价与药效物质研究,负责人：王一涛;国家重点基础研究发展计划(“973”)(2009CB522707)：“肺与大肠相表里”脏腑相关理论的应用基础研究之第七课题：基于药代动力学和代谢组学的肺与大肠相表里归经中药研究,负责人：王一涛.

摘　　要：中药药物代谢动力学(中药药动学)研究是近年来兴起的中药研究的新领域,研究了一些中药和复方,提出了一些相关的理论假说,但总体上尚处于初期的探索阶段,需进一步地深入研究。本文总结与评述了中药药动学近年来的研究进展,探讨了中药药动学的概念、中药药动学研究的特点与难点,从而提出了基于药效物质基础的中药药动学研究模式的设想。The pharmacokinetic study of Chinese medicine （CM） is a new research direction in recent years. The pharmacokinetics of some CM and its formula have been investigated and a number of related theories and hypotheses have been proposed, which provide some insights into this area. However, the overall studies in this aspect were still at the early exploratory stage and further studies are needed. This paper summarizes the recent advances, interprets the definition, characteristics and difficulties of CM pharmacokinetic study. The authors proposed the material basis-based evaluation model for CM pharmacokinetic study.

关 键 词：中药 药物代谢动力学 药效物质基础 

分 类 号：R969.1[医药卫生—药理学]