转化理念指导下的芍药甘草汤抗炎止痛实验研究  

Experimental Study on Anti-inflammatory and Pain-relieving Effects of Shaoyao Gancao Decoction Based on Translational Medicine

作　　者：隋峰[1] 李兰芳[1] 李珊[1] 郭淑英[1] 霍海如[1] 姜廷良[1] 

机构地区：[1]中国中医科学院中药研究所唐氏中药研究中心,北京100700

出　　处：《世界科学技术-中医药现代化》2011年第1期188-192,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金面上项目(30873393):芍药甘草汤干预TRPV_1通路的止痛分子机理及其配伍机制;负责人:隋峰;国家自然科学基金面上项目(30672677):基于瞬变感受器电位离子通道蛋白(TRPs)的中药四性分子机制研究;负责人:霍海如;北京市自然科学基金面上项目(7092074):芍药甘草汤干预TRPV_1通路的止痛机理与配伍机制;负责人:隋峰

摘　　要：目的:揭示芍药与甘草的配伍机理,评价芍药、甘草以及芍甘1:1组对佐剂性关节炎的疗效和药效学特征。方法:采用完全佛氏佐剂复制大鼠关节炎模型,分别给予芍药、甘草以及芍药甘草汤灌胃治疗,观察并分析大鼠的行为学、足温、痛阈以及关节肿胀度的变化。结果:大鼠注射完全佛氏佐剂后,体重明显减轻,足温升高,痛阈降低,关节肿胀明显;各给药组对上述指标均有不同程度的逆转作用,尤以芍甘1:1组最为明显。结论:芍药、甘草以及芍药甘草汤对大鼠佐剂性关节炎均有明显的治疗作用,且以芍药和甘草配伍组效果最佳。This study aimed to uncover the compatibility mechanism of Paeonia lactifiora （Shaoyao） with Radix Glycyrrhiza （Gancao） and evaluate the therapeutic effects and characteristics in the treatment of adjuvant arthritis by Shaoyao, Gancao and the combination of Shaoyao with Gancao （1：1）. Adjuvant arthritis rat models were experimentally established with Freund＇s complete adjuvant. The behavior, foot temperature, pain threshold and swelling degree of the rat models were observed and analyzed. The data showed that after injection, the rats presented with decreased weight, increased foot temperature, decreased pain threshold and significant joint swelling. After drug administration, pathological changes mentioned above were gradually reversed. The group administered intragastrically with the combination of Shaoyao with Gancao （1：1） is the one with obvious symptom-relieving profile. The results indicated that all drugs applied in this study have obvious therapeutic effect in the treatment of adjuvant arthritis and the combination group presented with the best therapeutic effect.

关 键 词：转化医学 芍药甘草汤 佐剂性关节炎 抗炎 止痛 

分 类 号：R289.5[医药卫生—方剂学]