骨质疏松椎体骨折患者药物治疗现状调查  

Survey on medical therapy of patients with osteoporotic vertebrae fractures

作　　者：金晖[1] 蔡若男[1] 何仕诚[2] 邓钢[2] 

机构地区：[1]东南大学附属中大医院内分泌科,南京210009 [2]东南大学附属中大医院介入血管科,南京210009

出　　处：《中华内分泌代谢杂志》2011年第2期110-112,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的调查骨质疏松椎体骨折患者骨质疏松相关评估和药物治疗情况。方法对2006年5月至2009年12月期间在本院行椎体成形术的骨质疏松椎体骨折患者通过病例回顾及电话随访的方式进行调查，排除因外伤、肿瘤转移所致的椎体骨折患者。调查内容包括骨密度检查、钙和维生素D的补充、抗骨质疏松药物的使用情况。结果253例患者中进行过骨密度检查的患者极少，仅为3．6％，补充钙剂患者占9．5％，补充维生素D者占6．7％。使用抗骨质疏松药物者占36％，在所使用抗骨质疏松药物中双膦酸盐占27．5％，降钙素者29．7％，静滴骨肽者2．2％，中药制剂如强骨胶囊等占3．3％，对所服用药物不详者约占37．4％。结论大多数骨质疏松椎体骨折患者除了外科手术对症处理外并没有接受抗骨质疏松药物治疗和相应的检查，应重视骨质疏松骨折的综合处理，对高危人群进行筛查和适当的药物治疗，以防止再次骨折的发生。Objective To evaluate the efficacy of medical therapy in the patients with osteoporotic vertebrae fracture. Methods The patients suffered from vertebrae fracture and had undergone percutaneous vertebroplasty operation were reviewed from May, 2006 to December, 2009. Informations were collected via case evaluation and telephone interview, regarding dual-energy X-ray absorptiometry （ DXA ）, calcium and vitamin D supplementation, and anti-osteoporosis drugs treatment. Patients with fracture induced by trauma and tumor metastasis were excluded. Results Among 253 patients, DXA was performed only in 3.6% of patients. Calcium and vitamin D supplements were prescribed in 9.5 % and 6.7 % of patients, respectively. Anti-osteoporosis drugs were prescribed in 36% of patients, of them 27.5%, 29.7%, 2.2%, and 3.3% received bisphosphonate, calcitonin, ossotide, and traditional Chinese drugs respectively. 37. 4% of patients could not recall the name of the drug they had received. Conclusions Most patients with osteoporotic vertebrae fracture do not receive adequate anti-osteoporosis drugs or appropriate evaluation. More care should be given to the patients with vertebrae fracture, with regard to adequate drug treatment and appropriate evaluation in order to prevent future fractures.

关 键 词：骨质疏松 椎体骨折 药物治疗 

分 类 号：R580[医药卫生—内分泌] R683[医药卫生—内科学]