非糖尿病人群中补体C3、超敏C反应蛋白与胰岛素抵抗指数（HOMA2-IR）相关性分析  

Association of complement component 3 and high-sensitive C-reactive protein with insulin resistance index （HOMA2-IR） in non-diabetic population

作　　者：王邦琼[1] 李启富[1] 蒋袁娟[1] 刘洲君[1] 钟立[1] 程庆丰[1] 青华[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,400016

出　　处：《中华内分泌代谢杂志》2011年第2期133-136,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（30700271）

摘　　要：目的观察非糖尿病人群血清补体C3、超敏C反应蛋白（hs-CRP）水平及其与胰岛素抵抗的关系。方法纳入587例非糖尿病个体，测定体重、身高、血压、腰围、空腹血浆葡萄糖、血清胰岛素、血脂、补体C3及hs—CRP等，计算胰岛素抵抗指数（HOMA2-IR）。以HOMA2-IR上四分位为切点划分胰岛素抵抗与非胰岛素抵抗。结果胰岛素抵抗人群补体C3和hs—CRP显著高于非胰岛素抵抗人群。校正性别、年龄、BMI及腰围后，部分相关分析发现补体C3与HOMA2—IR显著正相关（r=0．19，P〈0．01）。去除性别、年龄、收缩压、舒张压、总胆固醇、甘油三酯、高密度脂蛋白胆固醇和腰围的影响后，随着补体C3的升高发生胰岛素抵抗的危险增加3．78倍（OR=3．78，P〈0．05）；而hs-CRP与胰岛素抵抗的发生无统计学意义。结论在非糖尿病人群中，补体C3与胰岛素抵抗的相关性强于hs-CRP。Objective To observe and compare the association of serum levels of of complement component 3 （ C3 ） and high-sensitive C-reactive protein（hs-CRP） with insulin resistance in non-diabetic subjects. Methods 587 non-diabetic Chinese were recruited. Weight, height, blood pressure, waist circumference, fasting plasma glucose, fasting serum insulin, blood lipids, C3 and hs-CRP were measured. HOMA index （HOMA2-IR） was calculated. Insulin resistance was defined as the upper quartile of HOMA2-IR. Results C3 and hs-CRP were significantly higher in subjects with insulin resistance compared with subjects without insulin resistance. After controlling for age, gender, body mass index, and：waist circumference, C3 was positively and significantly correlated with HOMA2-IR （ r = 0.19, P〈0.01 ）. As C3 increased, subjects were 3.78 （ OR = 3.78, P 〈 0.05 ） times more likely to suffer from insulin resistance, after adjustment for age, gender, systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides,high-density lipoprotein cholesterol, and waist circumference. However, hs-CRP was not significantly correlated with insulin resistance. Conclusions Serum complement component 3 has a more marked association with insulin resistance than hs-CRP in non-diabetic Chinese.

关 键 词：胰岛素抵抗 超敏C反应蛋白 补体C3 

分 类 号：R587.1[医药卫生—内分泌]