阿法骨化醇软胶囊治疗膝关节骨性关节炎的疗效观察  

Clinical observation of the effect of alpha-calcidol on treatment of osteoarthritis of the knee

作　　者：王银河[1] 翁文杰[1] 朱丽华[1] 任杰[1] 李文[1] 陆涛[1] 邱勇[1] 

机构地区：[1]南京大学医学院附属鼓楼医院骨科,南京210008

出　　处：《中国骨质疏松杂志》2011年第2期142-144,157,共4页Chinese Journal of Osteoporosis

摘　　要：目的探讨阿法骨化醇(法能)对膝关节骨性关节炎的疗效。方法对门诊37例膝关节骨性关节炎的患者给予阿法骨化醇软胶囊(法能)结合非甾体止痛药治疗并观察其疗效。结果 37例按WOMAC骨关节炎指数评分结合5点口述评分法评价疗效,优良率78.37%(29/37),显著效果29.73%(11/37),经采用该治疗方法后其典型症状均明显改善。服药期间未发现不良反应。结论采用法能结合非甾体止痛药治疗膝关节骨性关节炎,可有效改善患者的疼痛及活动受限症状,效果满意。Objective To explore the efficacy of alpha-calcidol on treatment of osteoarthritis of the knee （KOA）. Methods Thirty-seven patients of KOA in the outpatient department were administered with oral alpha-ealcidol soft capsules combined with NSAIDs to observe the drug efficacy. Results The efficacy of the treatment was evaluated with WOMAC Osteoarthritis Index Guide and VRS-5. After a course of alphacaleidol combined with NSAIDs treatment, the total effectiveness was 78.37% （29/37） , and the obvious effectiveness was 29. 73% （11/37）. The typical symptoms were released after the treatment. No adverse effect was found during the treatment. Conclusion Using alpha-calcidol combined with NSAIDs treatment for KOA could release the pain and limitation of activity of the patients. The effect was satisfied.

关 键 词：骨性关节炎 膝关节 阿法骨化醇软胶囊(法能) 门诊治疗 

分 类 号：R969[医药卫生—药理学]