中国人群肿瘤坏死因子α基因-308A/G多态性与哮喘易感性的Meta分析  

Tumor Neorosis is Factor-α-308A/G polymorphism and as thma susceptibility in Chinese population:A meta-analysis

作　　者：杨炼[1] 李晋蜀[1] 王雪梅[1] 王次林[1] 

机构地区：[1]成都市儿童医院检验科呼吸科,四川成都610017

出　　处：《四川医学》2011年第3期418-421,共4页Sichuan Medical Journal

摘　　要：目的利用Meta分析探讨中国人群肿瘤坏死因子α(TNF-α)基因-308A/G多态性位点与哮喘易感性关系。方法检索PubMed,Medline(Ovid),EMbase,ScienceDirect,Springer,CNKI,万方,维普数据库,收集研究中国人群TNF-α-308A/G多态性位点与哮喘易感性的文献进行Meta分析。利用Revman4.2软件和STATA10.0软件进行统计学分析。结果根据纳入排除标准,总计纳入9篇文献进行研究,累计病例和对照数分别为1361例和1360例。TNF-α突变基因型(AA+AG)个体得哮喘发病风险为野生型GG个体的1.47倍(95%CI:1.09～1.97,P=0.01)。发表偏倚评估未发现明显的发表偏倚,敏感性分析显示meta分析结果可信。结论 TNF-α-308A/G多态性位点与中国人群哮喘易感性密切相关,突变基因型携带者的哮喘发病风险较高。Objective To investigate the association between the-308A/G polymorphism of TumorNecrosis Factor-α（TNF-α）gene and asthma susceptibility in Chinese population.Methods We searched Medline（Ovid）,PubMed,EMabase,ScienceDirect,Springer,CNKI,Wanfang Database,Weipu database.Statistical analysis was performed with the software program Revman4.2 and STATA 10.0.Results A total of nine articles were included in our meta-analysis based on the inclusion criteria.There were 1361 cases and 1360 controls.The variant genotypes were significantly associated with asthma risk in Chinese population,the OR was 1.47 with the 95%CI：1.09～1.97,P=0.01.Publication bias was not significant in the meta-analysis;results of sensitivity analysis indicated the stability of the meta-analysis.Conclusion The-308A/G polymorphism in TNF-α gene was associated with increased asthma risk in Chinese population.The variant genotypes carriers may increase risk of asthma.

关 键 词：哮喘 多态性 肿瘤坏死因子Α META分析 

分 类 号：R562.25[医药卫生—呼吸系统]