子宫球蛋白基因G38A多态性与IgA肾病的相关性研究  

Association of uteroglobin gene G38A polymorphysm with IgA nephropathy

作　　者：熊瑜[1] 甘华[1] 钟清[1] 

机构地区：[1]重庆医科大学附属第一医院肾脏内科,400016

出　　处：《重庆医学》2011年第9期851-852,855,共3页Chongqing medicine

摘　　要：目的探讨IgA肾病(IgAN)患者子宫球蛋白(UG)基因G38A多态性的分布特点,及其与IgAN病理改变之间的关系。方法选取经肾穿刺病理活检证实为IgAN的患者102例,提取外周血基因组DNA,以聚合酶链反应-限制性片段长度多态性(PCR-RFLP)确定UG基因G38A基因型,分析不同基因型频率及其与IgAN病理改变之间的关系。结果 IgAN患者UG基因G38A的3种基因型中基因型GA的频率分布与对照组比较差异有统计学意义(P=0.005),UG基因G38A多态性与IgAN病理改变无相关性。结论 UG基因G38A多态性与中国人群IgAN的发病有关,与病理改变严重程度无相关性。Objective To clarify whether the UG gene G38A polymorphism is connected to human IgAN in both incidence and pathological changes.Methods Totally 102 IgAN patients proved by renal biopsy were recruited,genetic DNA was extracted from blood,and genotypes were detected by PCR-RFLP.The frequency of different genotypes was analyzed to find the relationship between them and the clinical pathological changes in IgAN.Results There was significant difference among the three genotypes of UG gene between IgAN patients and healthy people（P=0.005）.The frequency of three genotypes had no significant relationship with clinical manifestations and pathological changes in IgAN patients.Conclusion UG gene G38A polymorphism is related to the incidence of IgAN in Chinese people,but it is not related to the pathological changes.

关 键 词：肾小球肾炎 IgA 子宫球蛋白 G38A 

分 类 号：R692[医药卫生—泌尿科学]