3-羰基-10-去甲基-12-甲氧基松香烷的全合成  

Total synthesis of 3-carbonyl-10-demethyl-12-hydroxyabietane

作　　者：张成路[1] 徐德青[1] 邵懿[1] 周龙[1] 曲瑞峰[1] 高丽娜[1] 

机构地区：[1]辽宁师范大学化学化工学院,辽宁大连116029

出　　处：《辽宁师范大学学报（自然科学版）》2011年第1期71-73,共3页Journal of Liaoning Normal University:Natural Science Edition

基　　金：辽宁省教育厅科学技术研究项目(2009A426);辽宁省高校创新团队项目(2008T107)

摘　　要：按照AC→ABC的合成策略,设计了1种新的合成路线,并合成了目标产物3-羰基-10-去甲基-12-羟基松香烷.在合成中,以2-异丙基苯甲醚为原料,在磷钼酸铵催化下,经过对位溴代、与环氧乙烷加成和苄醇溴代等反应步骤,合成了3-羰基-10-去甲基-12-甲氧基松香烷13,总收率达14.17%.通过红外光谱、核磁共振谱和质谱等结构表征,结果表明成功实现了目标产物的全合成.Total Synthesis of 3-Carbonyl-10-demethyl-12-hydroxyabietane was explored according to the strategy of AC→ABC.The 13 was synthesized from 2-isopropyl-1-methoxybenzene by bromination in the presence of the catalyst ammonium molybdate,the addition of ethylene epoxide and further bromination.All intermediates and target product were confirmed by IR,1H NMR and MS.In conclusion,a simple high yield synthetic route has been developed and the target molecule was successfully synthesized.

关 键 词：松香烷 全合成 结构表征 

分 类 号：O629[理学—有机化学]