初发2型糖尿病患者血糖控制与血小板参数的相关性研究  

Relationship between glycemic control and platelet parameters in newly diagnosed type 2 diabetic patients

作　　者：唐建东[1] 李清楚[1] 康志强[1] 何丽[1] 罗方[1] 雷龙涛[1] 

机构地区：[1]河南省郑州市中心医院内分泌科,450007

出　　处：《中国综合临床》2011年第3期267-269,共3页Clinical Medicine of China

摘　　要：目的探讨初发2型糖尿病患者血糖控制与血小板参数的相关性。方法检测90例住院或门诊初发2型糖尿病患者和90名健康体检者的血压和血小板参数，包括血小板计数（PLT）、血小板平均体积（MPV）和血小板体积分布宽度（PDW）、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL—C）等指标，对治疗3个月后HbA1C达标（≤7％）的2型糖尿病患者重复测定上述参数。结果（1）初发2型糖尿病组FBG、TC、TG、MPV及PDW均高于健康对照组（t值分别为6．405、2．069、2．633、2．178、2．103，P值分别为0．001、0．046、0．010、0．031、0．043）。（2）HbA1c〉7％的糖尿病患者48例，FBG、HbA1c、TC、TG、MPV及PDW均高于HbA1c≤7％组（t值分别为5．691、2．013、2．345、3．467、4．016、2．893，P值分别为0．001、0．038、0．029、0．013、0．004、0．026）；糖尿病患者MPV与HbA1c（r=0．389，P=0．020）、PDW（r=0．324，P=0．010）呈正相关；与FBG（r=0．098，P=0．370）、收缩压（r=0．060，P=0．587）及舒张压（r=0．046，P=0．784）均无相关性。（3）HbA1c达标的糖尿病患者36例，控制血糖后FBG、HbA1c、TG、MPV、PDW较治疗前均有下降（t值分别为5．591、2．301、2．410、2．204、2．105，P值分别为0．001、0．031、0．023、0．035、0．041）。结论初发2型糖尿病患者的血小板活性增强，控制血糖可降低血小板活性，对防治糖尿病血管并发症有益。Objective To study the relationship between glycemic control and platelet parameters in newly diagnosed type 2 diabetic patients. Methods Ninety patients newly diagnosed as type 2 diabetes and 90 healthy people were enrolled into the study. Their blood pressure, platelet parameters, including blood platelets count （PLT） , mean ptatelet volume （ MPV ） , platelet distribution width（PDW） , fasting blood gtucose（FPG） , HbA1 c, triglyceride （ TG ）, total cholesterol （ TC ）, high density lipoprotein cholesterol （ HDL-C ）, low density lipoprotein cholesterol（LDL-C） were examined and the data were analyzed. Results The level of FBG, TG, TC, MPV and PDW of patients newly diagnosed as type 2 diabetic were significantly higher than those of healthy people （ t = 6. 405,2. 069,2. 633,2. 178,2. 103 ;P = 0. 001,0. 046,0. 010,0. 031 and 0. 043 respectively） ; The level of FBG, HbA1 c, TC, TG, MPV and PDW in the diabetic patients, with their HbA1 c 〉 7% , were significantly higher than the patients with HbA1c≤7% （t =5. 691,2. 013,2. 345,3.467,4. 016,2. 893 ,P =0. 001,0. 038, 0. 029,0. 013,0. 004,0. 026 ） . There were positive correlations between MPV and HbA1 c （ r = 0. 389 P = 0. 020）,MPV and PDW（r =0. 324 P =0. 01 ）in diabetic patients,but no correlation between MPV and FBG, MPV and Systolic BP or MPV and Diastolic BP （ Ps 〉 0.05 ）. The level of FBG, HbA1 c, TG, MPV and PDW decreased significantly in the diabetic patients with HbA1 c 〉 7% after treatment （ t = 5. 591,2. 301,2. 410, 2. 204,2. 105 ; P = 0. 001,0. 031,0. 023,0. 035,0. 041, respectively ）. Conclusion The platelet activity enhanced in newly diagnosed type 2 diabetic patients, platelet activity can be recovered through glycemic control, which may prevent the role of platelet in diabetes complications in these patients.

关 键 词：2型糖尿病 血小板参数 血糖 

分 类 号：R587.1[医药卫生—内分泌]