杜仲雄花茶对四氯化碳致小鼠肝损伤的保护作用  

Protection effects of Eucommia ulmoides male flower tea on carbon tetrachloride induced liver injury in mice

作　　者：娄丽杰[1] 陈百泉[1] 杜红岩[2] 付建敏[2] 杜兰英[2] 李钦[1] 

机构地区：[1]河南大学中药研究所,河南开封475004 [2]中国林业科学研究院经济林研究开发中心,河南郑州450003

出　　处：《河南大学学报（医学版）》2011年第1期24-26,共3页Journal of Henan University:Medical Science

基　　金：国家林业公益性行业专项(201004029);国家"948"项目(2008-4-66);河南省科技攻关重点项目(102102310188);河南省教育厅自然科学基金(2008A360003)

摘　　要：目的:探讨杜仲雄花茶对四氯化碳致小鼠肝损伤的保护作用。方法:将50只昆明小鼠随机分5组,分别为空白对照组、甘草酸二铵组、模型组、杜仲雄花高剂量组和杜仲雄花低剂量组,按标准给药饲养14 d后,腹腔注射体积分数为0.1%四氯化碳油溶液20 mL/kg,16 h后测各组小鼠血清谷丙转氨酶(ALT)和谷草转氨酶(AST)。结果:与模型组相比,杜仲雄花茶高剂量组小鼠的ALT,AST水平明显偏低。结论:杜仲雄花茶对四氯化碳致小鼠肝损伤具有保护作用。Objective：To study the protection effects of Eucommia ulmoides male flower tea on carbon tetrachloride induced liver injury in mice.Methods：50 mice were divided into 5 groups at random,the control group,diammonium glycyrrhizinate control group,the carbon tetrachloride model group,high dose group and low dose group,which were given medicines at the standard doses for 14d,namely intraperitoneal injection 0.1% diammonium glycyrrhizinate dissolved by greasy 20 mL/kg after the last administration.Alanin aminotransferase（ALT）and Aspartate aminotransferase（AST） in the serum were determined after 16 hours.Results： Serum ALT,AST of high dose group of Eucommia ulmoides male flower tea in mice stepped down in comparison with the carbon tetrachloride model group.Conclusion： Eucommia ulmoides male flower tea has the protection effects of Eucommia ulmoides male flower tea on carbon tetrachloride induced liver injury in mice.

关 键 词：杜仲雄花茶 四氯化碳 肝损伤 

分 类 号：R285.5[医药卫生—中药学]