头低位(-20°)限制活动7d对兔庆大霉素药代动力学的影响  

Effects of 7 d Head Down Tilt(-20°) Immobilization on Pharmacokinetics of Gentamicin in Rabbits.

作　　者：郭志峰[1] 高建义[1] 王宝珍[1] 石宏志[1] 王静[1] 钱锦康[1] 

机构地区：[1]航天医学工程研究所,北京100094

出　　处：《航天医学与医学工程》1999年第5期333-337,共5页Space Medicine & Medical Engineering

摘　　要：目的 探讨模拟失重条件下以血流量改变为生理基础的药代动力学变化。方法 选择庆大霉素作为模型药物，采用头低位（ － ２０°） 兔限制活动为模拟失重动物模型，观察模拟失重对兔庆大霉素药代动力学参数的影响。７ 只家兔在头低位７ ｄ 前后，分别静脉滴注了３ ｍｇ／ｋｇ 的庆大霉素，用 Ｔ Ｄｘ Ｆ Ｌｘ 测定了给药后４ ｈ 内的血药浓度。结果 庆大霉素的分布变慢，这表现在α值由头低位前的（０ ．１８３８ ±０ ．１０７６）ｍｉｎ － １ 降至头低位后的（０ ．０５９１ ±０ ．０３３４） ｍｉｎ － １ ，ｔ１／２α由（５ ．３０ ±３ ．５５） ｍｉｎ 延长为（１５ ．０４ ±７ ．４９）ｍｉｎ ， Ｋ１２ 由（０ ．１０２５ ±０ ．０７２１） ｍｉｎ － １ 降至（０ ．０１８１ ±０ ．０１６１） ｍｉｎ１ ，都有显著性差异； Ｖ（ Ｃ） 、 Ｖ（ Ｄ） 也有升高的趋势。庆大霉素清除率在模拟失重后也有所增加， Ｃ Ｌ（ Ｓ） 从（２ ．２ ±０ ．５）ｍｌ·ｍｉｎ１·ｋｇ１ 升至（２ ．７ ±０ ．３）ｍｌ·ｍｉｎ１·ｋｇ１ 。结论 模拟失重可改变药代动力学过程。Objective To observe pharmacokinetic changes under simulated weightlessness in relevant to body flood flow changes. Method Gentamicin was selected as probe drug in the present study, and rabbits exposed to Head Down Tilt( HDT,-20°) immobilization were selected as simulated weightlessness animal model. Seven rabbits were treated inf. with 3 mg/kg of gentamicin sulfate pre HDT and 7 d after HDT. Gentamicin blood samples within 4 h after administration were analyzed by TDxFLx. Result The distribution of gentamicin postponed significantly: a significant decrease in α from (0.1838± 0.1076 )min -1 before HDT to (0.0591±0.0334)min -1 after HDT; a significant increase in t 1/2 α from (5.30±3.55)min to (15.04±7.49)min;a significant decrease in k 12 from (0.1025±0.0721)min -1 to (0.0181±0.0161)min -1 ,a increase trend in V (C) and V (D) . After HDT, CL (S) of gentamicin increased from (2.2±0.5)ml·min -1 ·kg -1 to (2.7±0.3)ml·min -1 ·kg -1 . Conclusion Simulated weightlessness might induce pharmacokinetic changes.

关 键 词：失重模拟 药代动力学 庆大霉素 兔 

分 类 号：R852.22[医药卫生—航空、航天与航海医学] R859[医药卫生—临床医学]