天麻醇提物对旋转诱发小鼠运动病的影响  

Effect of Gastrodia on Rotation Induced Motion Sickness in Mice.

作　　者：王圣平[1] 刘新民[1] 尚伟芬[1] 宋洁[1] 于澍仁 孙绍美[1] 

机构地区：[1]中国协和医科大学中国医学科学院药用植物研究所,北京100094

出　　处：《航天医学与医学工程》1999年第5期342-345,共4页Space Medicine & Medical Engineering

基　　金：国家科委博士点基金

摘　　要：目的 观察天麻醇提物对旋转诱发小鼠运动病的影响。方法 利用转椅进行角加速度旋转来诱发运动病，观察小鼠进食量、自主活动度及在方形水迷宫中学习记忆空间辨别能力及天麻醇提物对其的影响。结果角加速度旋转后能引起小鼠厌食、自主活动降低及在方形迷宫中出现空间辨别障碍。天麻醇提物能提高旋转后小鼠的自主活动度，改善厌食症状，提高旋转后小鼠在水迷宫中的空间辨别能力。结论 天麻醇提物能改善旋转诱发小鼠运动症状。Objective To observe the effect of Gastrodia on motion sickness induced by rotation in mice. Method Clockwise and anticlockwise accelerated rotations up to 180°/s for 10 min were used to induce symptoms of motion sickness such as condition taste aversion(CTA) , decrease of spontaneous locomotion and impaired ability of space identification in water maze. Result Gastrodia could improve the response of CTA, increase spontaneous locomotion, and enhance the ability of learning and memory in water maze in mice after the rotation. Conclusion Symptoms of motion sickness induced by rotation could be improved by Gastrodia treatment.

关 键 词：天麻醇提物 旋转 运动病 空间定向障碍 水迷宫 

分 类 号：R852.23[医药卫生—航空、航天与航海医学] R859[医药卫生—临床医学]