妊娠期高血压疾病患者血清中sEng及TNF-α的表达及其相关性分析  

Expression and correlation of serum soluble endoglin and TNF-α in pregnancy-induced hypertension

作　　者：吕敬媛[1] 赵玉楠[1] 王丹[1] 

机构地区：[1]佳木斯大学附属第一医院妇产科,黑龙江佳木斯154003

出　　处：《黑龙江医药科学》2011年第1期11-12,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:探讨可溶性endoglin(sEng)和肿瘤坏死因子(TNF-α)在妊娠期高血压疾病患者及正常晚期妊娠妇女血清中的表达意义,分析二者的相关性及在疾病发生发展中的作用。方法:通过ELISA法检测妊娠期高血压疾病患者及正常晚期妊娠妇女血清中sEng及TNF-α的表达。结果:(1)妊娠期高血压疾病患者sEng水平明显高于正常晚孕组,差异有统计学意义。sEng的表达随疾病进展而升高,各组间差异具统计学意义。(2)TNF-α在正常晚孕妇女及妊娠期高血压疾病子痫前期轻度组,子痫前期重度组,子痫组血清中表达水平逐渐升高,四组间两两差异具统计学意义。(3)妊娠期高血压疾病组血清中sEng和TNF-α的表达水平呈显著正相关关系(r=0.91,P<0.01)。结论:妊娠期高血压疾病患者血清中sEng和TNF-α表达升高,升高水平随疾病进展而加重;sEng和TNF-α表达呈正相关,可能TNF-α升高使sEng表达增加。Objective：To investigate the expression of serum soluble endoglin（sEng） and tumor ncrosis factor-α（TNF-α）in pregnancy-induced hypertension（PIH） and in normal late pregnancy and analyze the correlation between sEng and TNF-α and the role of sEng and TNF-α in the occurrence and development of PIH.Methods：We detected the serum levels of sEng and TNF-α in PIH and normal late pregnancy by using enzymelinked immunoassay kits.Results：（1）The serum sEng level in PIH was significantly higher than that of normal pregnancy.The serum sEng expression level in PIH was increased with disease developing（P〈0.05）.（2）The serum TNFα levels in normal pregnancy group and the mild pre-eclampsia group,the severe pre-eclampsia group and eclmpsia group were gradually increased（P〈0.05）.（3）There was a significantly positive correlation between the serum sEng level and TNF-α level in PIH（r=0.91,P〈0.01）.Conclusion：Both serum sEng and TNF-αexpression levels are increased in PIH and are correlated with disease severity.The higher level of the serum TNF-α might stimulate the sEng expression.

关 键 词：妊娠期高血压疾病 可溶性ENDOGLIN 肿瘤坏死因子TNF-Α 

分 类 号：R714.246[医药卫生—妇产科学]