阿托伐他汀序贯疗法对冠状动脉支架置入术后患者预后的影响  

Effects of sequential therapy of atorvastatin on coronary stent implantation

作　　者：曾繁芳[1] 刘幼文[1] 金光临[1] 王涓[1] 潘楚梅[1] 师姗姗[1] 张雪[1] 曹高镇[1] 王灵芝[1] 

机构地区：[1]广东省深圳市孙逸仙心血管医院内五科,518020

出　　处：《广东医学》2011年第4期508-510,共3页Guangdong Medical Journal

摘　　要：目的探讨阿托伐他汀序贯疗法对冠状动脉支架置入术后患者再狭窄和临床远期疗效的影响。方法将确诊冠心病并行支架置入术治疗的125例患者分为观察组和对照组;观察组术前阿托伐他汀80 mg顿服,术后改40 mg/次,1次/d,30 d后再改为20 mg/次,1次/d;对照组维持20 mg/次,1次/d。观察治疗后6个月血脂、管腔造影情况、心血管事件发生率等指标的变化。结果观察组LDL、HDL、最小管腔直径和狭窄百分比等指标与对照组相比有明显改善,差异有统计学意义(P<0.05)。观察组心血管事件的发生率明显少于对照组(P<0.05)。结论阿托伐他汀序贯疗法能够有效地减少支架置入术后再狭窄,降低术后心血管事件的发生率,改善患者预后。Objective To evaluate the effect of sequential therapy of atorvastatin on coronary stent implantation in prevention of restenosis. Methods Coronary stent implantation was performed in 125 patients with coronary artery disease. The subjects were randomly divided into experimental group and control group. Blood lipids, coronary angiography and cardiovascular events were observed for analysis. Results Significantly better outcome in LDL, HDL, minimum lumen diameter, stenosis and cardiovascular events rates was revealed in experimental group （P 〈 0.05 ）. Conclusion Atorvastatin effectively reduces restenosis and cardiovascular events after stenting and improve the prognosis.

关 键 词：阿托伐他汀 血管成形术 经腔 经皮冠状动脉 支架 再狭窄 冠状动脉疾病 

分 类 号：R654.2[医药卫生—外科学]