微透析技术监测颅脑损伤患者脑白介素6和白介素8水平对预后的评价意义  

Significance of Intracerebral IL-6 and IL-8 Levels Detected by Microdialysis on the Prognosis of Patients with Traumatic Brain Injury

作　　者：孙强 宋伟健 林文娟 胡继良 魏强国 杨振九 胡深 

机构地区：[1]广东省深圳市第六人民医院,南山区人民医院神经外科,518000

出　　处：《中国全科医学》2011年第6期616-618,共3页Chinese General Practice

基　　金：深圳市科技计划项目(200903271)

摘　　要：目的探讨微透析技术监测颅脑损伤患者脑白介素6(IL-6)和白介素8(IL-8)水平对其预后的评价意义。方法选择我院2006年3月—2009年11月颅脑外科和ICU收治的急性颅脑损伤患者32例,根据格拉斯哥昏迷量表(GCS)评分分为重度组和中度组,每组16例。利用微透析技术,提取患者手术当日以及术后第1、2、3、4天的微透析液。采用酶联免疫法对微透析液行IL-6和IL-8的检测并评价其与患者格拉斯哥预后量表(GOS)评分的关系。结果重度组患者手术当日和术后第1天微透析液IL-6和IL-8水平与中度组患者比较,差异均有统计学意义(P<0.05)。重度组和中度组患者IL-6水平和GOS得分呈正相关(P<0.05),而IL-8水平和GOS得分呈负相关(P<0.05)。结论微透析技术监测颅脑损伤患者IL-6和IL-8水平对患者预后评估有一定意义,但它是有创性操作,临床推广存在一定的难度,有待进一步研究。Objective To investigate the significance of intracerebral IL-6 and IL-8 levels detected by microdialysis on the prognosis of patients with traumatic brain injury.Methods 32 traumatic brain injury patients were divided into severe group（n=16） and moderate group（n=16） in compliance with their GCS scores.The microdialysis samples were then harvested respectively in the operation day and 1,2,3,4 days after operation.The IL-6 and IL-8 were measured by ELISA and their correlations with Glasgow outcome scores（GCS） of the patients were analyzed.Results The levels of IL-6 and IL-8 in the microdialysis samples of severe group were significantly higher than that in moderate group（P0.05）.The level of IL-6 in both severe group and moderate group was positively correlated with the GCS of the patients,while the level of IL-8 was negatively correlated with the GCS of the patients（P0.05）.Conclusion Intracerebral IL-6 and IL-8 levels detected by microdialysis can successfully forecast the prognosis of patients with traumatic brain injury.However,considering its invasiveness and patients′ tolerance,it is not easy to promote it clinically,and further study is needed.

关 键 词：颅脑损伤 微透析 白介素 预后 

分 类 号：R651.15[医药卫生—外科学]