糖脉康联合门冬胰岛素30对2型糖尿病患者血糖漂移及低血糖发生率的影响  

The Study of Glycemia Variability and Hypoglycemic Incidence in Type 2 Diabetes Mellitus Cured with Tangmaikang and Biphasic Insulin Aspart 70/30

作　　者：张宏武[1] 阿地力江.阿不力米提 全毅 伊力多斯.阿力什 蒋升[4] 

机构地区：[1]新疆维吾尔自治区人民医院内分泌科,新疆乌鲁木齐市830000 [2]新疆喀什地区第一人民医院内分泌科 [3]新疆五家渠市兵团农六师103团医院 [4]新疆医科大学第一附属医院内分泌科

出　　处：《中国全科医学》2011年第6期673-674,共2页Chinese General Practice

摘　　要：目的用动态血糖监测方法评价糖脉康颗粒联合门冬胰岛素30注射液治疗2型糖尿病时对患者血糖漂移及低血糖发生率的影响。方法选取64例2型糖尿病患者,随机分为观察组和对照组,各32例。两组均给予2次/d门冬胰岛素30注射液皮下注射,观察组另联合糖脉康颗粒3次/d口服。采用动态血糖监测的方法,评价两组患者血糖漂移幅度、日胰岛素用量及低血糖发生情况。结果血糖达标持续3个月后,观察组患者的日均胰岛素用量〔(28.6±7.4)U/d〕、日内血糖最高值〔(13.1±1.2)mmol/L〕、平均血糖漂移幅度〔(7.4±1.2)mmol/L〕均显著低于对照组〔分别为(35.4±5.2)U/d、(16.2±1.6)mmol/L、(8.4±1.7)mmol/L〕,差异有统计学意义(P<0.05);另外,观察组患者发生低血糖7人次(5例),对照组5人次(4例),两组患者低血糖发生率(15.6%与12.5%)比较,差异无统计学意义(P>0.05)。结论在血糖控制达标时,与单用门冬胰岛素30注射液比较,糖脉康颗粒联合门冬胰岛素30注射液治疗能降低2型糖尿病患者的血糖漂移幅度及日均胰岛素用量,且不增加低血糖发生率。Objective To analyze the influence on glycemia variability（GV） and hypoglycemic incidence by dynamic glucose monitoring in type 2 diabetes mellitus（T2DM） cured with biphasic insulin aspart 70/30 and Tangmaikang.Methods 64 patients with T2DM were randomly divided into experiment group and control group,with each group 32 patients.The control group was given single biphasic insulin aspart 70/30（two points/ day）,the experiment group was given Tangmaikang and biphasic insulin aspart 70/30（two points/ day）.Analyze the difference of GV,daily insulin dosage and hypoglycemic incidence by dynamic glucose monitoring between the two groups.Results Three months after the blood glucose met the standards,the daily insulin dosage（（28.6±7.4）U/d）,daily maximum value of blood glucose（（13.1±1.2）mmol/L）,average GV（（7.4±1.2）mmol/L） were all significantly lower than those of the control group,which were（35.4±5.2）U/d,（16.2±1.6）mmol/L and（8.4±1.7）mmol/L respectively（P0.05）.7 person-times hypoglycemic happened in experiment group,while 5 person-times happened in control group,the difference of hypoglycemic rate（15.6% vs 12.5%） between the two groups was not significant（P0.05）.Conclusion When blood glucose controlling meets standards,the combination of Tangmaikang and biphasic insulin aspart 70/30 can decrease glycemia variability and daily insulin dosage without increasing the incidence of hypoglycemic compared with when using biphasic insulin aspart 70/30 alone.

关 键 词：糖尿病 2型 糖脉康颗粒 门冬胰岛素30注射液 血糖漂移度 低血糖症 

分 类 号：R587.1[医药卫生—内分泌]