复方苦豆子对实验性动物血脂和血压的影响  

Effects of compound KUDOUZI on lipid and hypertension on the experiment animals

作　　者：王明远[1] 白婷[1] 刘小莉[2] 陈虹[2] 

机构地区：[1]新疆自治区人民医院,830000 [2]省部共建新疆特种植物药资源重点实验室

出　　处：《中国医学创新》2011年第7期11-13,共3页Medical Innovation of China

基　　金：新疆兵团省级医药专项资助项目(项目编号:04GG24)

摘　　要：目的观察复方苦豆子对实验性动物血脂和血压的影响。方法正常对照组除外,给鹌鹑喂饲高脂饲料建立高脂血症模型,模型复制成功后随机分成6组:正常对照组,高脂模型组,复方苦豆子高、中、低剂量组按24.4 g/(kg·d)、12.2 g/(kg·d)、6.1g/(kg·d)灌胃给药,血脂康组0.4g/(kg·d)。在第14周测定鹌鹑总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-Ch)、高密度脂蛋白-胆固醇(HDL-Ch)、动脉硬化指数(AI)。用两肾一夹法复制大鼠肾性高血压模型,模型成功后随机分成6组:正常对照组、高血压组、卡托普利组(5 mg/(kg·d))、复方苦豆子高、中、低剂量组(剂量同上),在第8、10周测定大鼠血压。结果与高脂模型组比较复方苦豆子能明显降低高脂血症鹌鹑血清中的TC、TG、LDL-C、Al,升高血清中的HDL-C;与高血压组比较能降低肾性高血压大鼠血压。结论复方苦豆子具有一定的调血脂及降压作用。Objectivve To observe effects of compound KUDOUZI on lipid and hypertension on exiperimental animals. Methods The coturnix hyperlipidemia model was established by feeding with high - fat diet in 7 weeks. After time model copied successfully, the groups randomized into 6 groups： normal group, control group, positive group （Xuezhikang 0. 4 g/（ kg· d） ）, High - dosage group（ KuDouZi 24.4 g/（ kg ·d） ）, Middle - dosage group（ KuDouZi 12.2 g/（ kg · d） ）, Low - dosage group（ KuDouZi 6. 1 g/（ kg· d） ） were administrated drugs. After 7 weeks, serum total cholesterol（TC）, triglyceride（ TG）, low density lipopertein cholesterol （ LDL - Ch） , high density lipoprotein cholesterol （ HDL - Ch） , artherios- cherosis index（AI） were measured. Renovascular hypertension rat model was estabished by using the method of two -kinney on clip（2K1 C）. After the model copied successfully, the groups randomized into 6 groups： normal group, control group, positive group （ Captopril 0. 4 g/（ kg · d） ） , Compound KUDOUZI High - dosage group, Middle - dosage group, Low - dosage group （same as above mentioned dosage）, Blood pressure was messured in the eighth week and tenth week. Results The level of serum TC, TG, LDL - Ch, Alin Positive group, High - dosage group, Middle - dosage group, Low - dosage group were obviously lower（P 〈0. 001, P 〈0. 01, P 〈0. 01, P 〈0. 05, P 〈0.01 ）, and the level of serum of HDL - Ch was higher than control group（P 〈0. 001, P 〈0. 05） ,and it can lower blood pressure than control group（P 〈0. 01 ,P 〈0. 05）. Conclusion Compound KUDOUZI has a effect on regulating the levels of serum lipids and reduce blood pressure.

关 键 词：复方苦豆子 调血脂 降血压 

分 类 号：R285.5[医药卫生—中药学]