不同年龄病人安定血药浓度与镇静深度的关系  

The Relationship between Plasma Concentrations and Sedative Depth of Diazepamin Patients with Different Age

作　　者：王若松[1] 梁炎基[1] 钱军[1] 王卫权 姚小莉[1] 

机构地区：[1]广州军区广州总医院,510010

出　　处：《临床麻醉学杂志》1999年第4期195-196,共2页Journal of Clinical Anesthesiology

摘　　要：目的 :观察不同年龄在腰麻下手术病人静脉内注射安定后血药浓度 (Cp)与镇静深度的关系。方法 :在 17例腰麻下手术病人中 ,测定安定的Cp和脑电双频谱指数 (BIS) ,并分析两者与镇静深度的关系。结果 :镇静评分为 0、1、2、3、4、5时安定Cp分别是 75 2± 3 5 9、65 2± 2 69、5 5 6± 193、4 88± 15 1、3 88± 13 2和 3 12± 12 8ng/ml。静脉给予安定0 2mg/kg后约 5 0分钟病人镇静评分降至 5分清醒水平。在同一镇静评分的情况下年龄较大的病人所测得Cp较低 ,两者呈负相关。结论 :BIS与镇静评分有较好相关 ,提示老年病人安定用量宜酌减。Objective: To observe the relationship among the measured diazepam concentraion, responsiveness of sedative scores and bispectral index(BIS) of EEG after an intravenous bolus of 0 1～0 2mg/kg of diazepam. Methods: In 17 patients operated under spinal anesthesia the Cp and BIS of i.v.diazepam were measured and co related with the depth of sedation. Results: The plasma drug levels at the sedative scores of 0,1,2,3,4 and 5 were752±359,625±269,556±193,488±151,388±132 and 312±128ng/ml respectively. After a bolus of 0 2mg/kg of diazepam, the plasma drug concentration decreased to the level of sedative score 5 in about 50 min. The plasma diazepam concentration required to reach the same sedative score decreased significantly as the age increased. Conclusion: BIS of EEG exhibits a good correlation with sedative scores. We suggest that the dose of diazepam should be decreased in old patients.

关 键 词：安定 镇静 脑电图 血药浓度 镇静深度 

分 类 号：R971.3[医药卫生—药品]