恶性肿瘤病人静吸复合麻醉中血过氧化物的变化  

Changes of SOD and LPO in Plasma and Erythrocyte in Cancer Patients during Combined Intravenous Inhalational Anesthesia

作　　者：严敏[1] 陈聪聪 柳子明[1] 周君富[2] 徐培华[1] 郦遇春[1] 徐亚男 张国英 

机构地区：[1]浙江医科大学附属第二医院麻醉科,杭州市310009 [2]浙江医科大学附属第二医院,杭州市310009

出　　处：《临床麻醉学杂志》1999年第4期201-205,共5页Journal of Clinical Anesthesiology

摘　　要：目的 :探讨恶性肿瘤病人静吸复合麻醉中血过氧化物的变化。方法 :观察 2 6例恶性肿瘤病人和 2 2例非肿瘤对照病人静吸复合麻醉中P LPO和E LPO及P SOD和E SOD变化 ,以及术中HR、MAP变化。结果 :两组LPO持续上升 ,SOD持续性下降 ,但无显著性差异 ,LPO于同一时间恶性肿瘤组明显高于非肿瘤组 ,SOD明显降低 ,而HR、MAP变化无显著性差异。结论 :静吸复合麻醉中心血管功能稳定 ,手术时间不长的情况下LPO、SOD无明显改变。恶性肿瘤组与非肿瘤组显著差异 ,并非由于麻醉的作用 ,而与恶性肿瘤病人术前自由基、脂质过氧化反应加速等因素有关。Objective: To examine the changes of SOD and LPO in plasma and erythrocyte in cancer patients under combined intravenous inhalational anesthesia. Methods: Both plasma and erythrocyte LPO (P LPO and E LPO), and both plasma and erythrocyte SOD (P SOD and E SOD) were measured before anesthesia, after intubation, one hour after anesthesia and at the end of surgery in 26 cancer patients. 22 non cancer patients served as control. Results: Although there were progressive increase of P LPO and E LPO, and progressive decrease of P SOD and E SOD in both groups, no significant difference was observed as compared with their baseline measurements. At each point of measurement, the cancer group had significantly higher P LPO and E LPO, and significantly lower P SOD and E SOD than that of the non cancer group. Conclusion: The combined intravenous inhalational anesthesia doesnt cause significant change of LPO and SOD in either cancer patients or non cancer patients, while the cardiovascular function is kept to be stable during relatively short period of surgery.

关 键 词：肿瘤 芬太尼 异氟醚 血过氧化物 综合麻醉 

分 类 号：R614.27[医药卫生—麻醉学] R730.56[医药卫生—外科学]