血脂康胶囊对不稳定性心绞痛患者血脂异常的影响  

Effect of Xuezhikang Capsule on Dyslipoproteinemia in Patients with Unstable Angina Pectoris

作　　者：戴小华[1] 卓秀珍[1] 汪玲[1] 薛晓阳[1] 杨文明[1] 俞兴群[1] 周宜轩[1] 

机构地区：[1]安徽中医学院第一附属医院心内科,合肥230031

出　　处：《中药新药与临床药理》1999年第4期202-204,共3页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：58例不稳定性心绞痛 (UA)合并血脂异常的患者随机分为两组 ,治疗组 3 3例 ,对照组 2 5例 ,均常规抗凝、抗血小板和抗心绞痛治疗 ,治疗组加用血脂康胶囊治疗 ,疗程均 8周。结果治疗组心绞痛及心电图总有效率分别为 75.8%和 66.7% ,与对照组比较 ,无显著性差异 ;血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、动脉硬化指数及血浆内皮素 (ET -1 )显著下降 ,高密度脂蛋白胆固醇及一氧化氮 (NO)显著升高 ,P <0 .0 5～ 0 .0 1。提示血脂康胶囊可能通过调整血脂、拮抗ET -1、促进NO释放 ,有效地阻止动脉粥样硬化。Fifty_five cases of unstable angina pectoris(UAP) with dyslipoproteinemia were allocated randomly to Group Ⅰ (33 cases) and Group Ⅱ (22 cases).Routine treatment including anticoagulant,antiplatelet and antiangenal therapies was given to the two groups and Xuezhikang Capsule (XC) was given to Group Ⅰ in addition.Results showed that the total effective rate for relieving angina was 75.8% and that for improving ECG was 66.7% in Group Ⅰ,the difference being not significant as compared with Group Ⅱ(P> 0.05) .Serum total cholesterol,triglyceride and low density lipoprotein cholesterol content,atherosclerosis index and plasm endothelin(ET_1) level were decreased,and high density lipoprotein cholesterol and nitric oxide(NO) level were increased in Group Ⅰ,the differences being significant as compared with Group Ⅱ (P< 0.01～0.05 ).It is suggested that XC can effectively inhibit atherosclerosis and protect the fuction of vascular endothelium by regulating blood lipid metabolism, antagonising ET_1 and enhancing the release of NO.

关 键 词：血脂康胶囊 不稳定心绞痛 高血脂症 

分 类 号：R259.892[医药卫生—中西医结合] R259.414[医药卫生—中医内科学]