对甲砜基苯丝氨酸铜合成的研究  

Synthesis of p-Methylsulfonylphenylserine Copper

作　　者：韩玉英[1] 宋健[1] 冯荣秀[1] 赵君彦[1] 

机构地区：[1]天津大学化工学院,天津30072

出　　处：《化学工业与工程》2011年第2期29-34,共6页Chemical Industry and Engineering

摘　　要：以对甲砜基苯甲醛、甘氨酸、硫酸铜为原料,氨水为催化剂,研究了对甲砜基苯丝氨酸铜的合成工艺。试验结果表明,制备对甲砜基苯丝氨酸铜的最适宜工艺为:n(对甲砜基苯甲醛)∶n(甘氨酸)∶n(硫酸铜)∶n(水)为1∶1.1∶0.55∶170,温度50℃,pH值为9,反应30 h,收率为80%左右。采用薄层色谱(TLC)、液质联机(LC-MS)以及红外光谱(IR)进行表征,探究并证实了该反应的机理并推测了所发生的副反应。The synthesis process of p-methylsulfonylphenylserine copper was studied in this paper.Methylsulfonylbenzaldehyde,glycine and copper sulfate were used as raw materials,and ammonia as catalyst.The results demonstrated the optimal conditions of the preparation process were as follows∶ p-methylsulfonylbenzaldehyde∶ glycine∶ copper sulfate∶ H2O = 1∶ 1.1∶ 0.55∶ 170（molar ratio）,reaction tempreture was 50 ℃,pH = 9,reaction time was 30 hours.The yield of p-methylsulfonylphenylserine copper was approximately 80% under the optimal conditions.And they were characterized by TCL,LC-MS and IR.The mechanism of the reaction was identified and the possible side reaction was speculated.

关 键 词：对甲砜基苯丝氨酸铜 合成 机理 副反应 

分 类 号：TQ460[化学工程—制药化工]