聚丙烯酸钠/壳聚糖互穿聚合物海绵的制备及应用探索  

Preparation and Application of Sodium Polyacrylate-Chitosan Interpenetrating Polymer Sponge

作　　者：范海波[1] 陈煜[1] 王东旭[1] 丛堃[1] 何谷[1,2] 张明明 周芳集[1] 

机构地区：[1]北京理工大学材料学院,北京100081 [2]中国石化北京化工研究院,北京100013

出　　处：《高分子材料科学与工程》2011年第3期120-123,共4页Polymer Materials Science & Engineering

基　　金：国家大学生创新性实验计划资助项目

摘　　要：以聚丙烯酸钠和壳聚糖为原料,以戊二醛为交联剂,在醋酸溶液中合成了聚丙烯酸钠/壳聚糖互穿聚合物,并采用冷冻诱导相分离法制备了具有多孔结构的海绵,用红外光谱(FT-IR)和扫描电镜(SEM)对其结构进行了表征,并研究了影响海绵溶胀性能的多种因素。实验结果表明,当mCTS∶mPAANa=1∶1.11、mCTS∶m戊二醛=1∶0.189时,可制得吸水倍率约为129 g/g,成型性能较好的多孔高吸水性海绵。在多孔海绵制备过程中加入对乙酰氨基酚,对药物在止血海绵中的释放性能的研究表明该海绵对模型药物有一定的缓释效果。Sodium polyacrylate-chitosan interpenetrating polymer network was synthesized in acetic acid solution with sodium polyacrylate and chitosan as raw materials,glutaraldehyde as crosslinker.After freezing dry,the interpenetrating polymer sponge was prepared.The molecular structure of the sponge was confirmed by Fourier transform infrared spectrum（FT-IR）,and the surface morphologies were examined by scanning electron microscope（SEM）.The factors of influencing the swelling properties were studied.It is found that the optimum reaction condition for synthesizing the sponge with the relatively good swelling properties was that mCTS∶mPAANa=1∶1.11,mglutaraldehyde∶mCTS=1∶0.189.The pores superabsorbent sponge prepared through these conditions could absorb over 129 g/g distilled water.The model drug acetaminophen was added during the process of preparing the sponge.It is found that the model drug immolilized in the network structure can be slow released from the sponge.

关 键 词：壳聚糖 聚丙烯酸钠 海绵 溶胀度 药物缓释 

分 类 号：TQ316.6[化学工程—高聚物工业]