Ghrelin在脓毒血症中的作用机制研究进展  

Development on Mechanism of The Role of Ghrelin in Sepsis

作　　者：彭志友[1] 封小美[1] 于布为[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院麻醉科,200025

出　　处：《麻醉与监护论坛》2011年第1期35-36,共2页Forum of Anesthesia and Monitoring

摘　　要：脓毒血症具有高发病率和高死亡率的特点。脓毒血症的治疗强调综合治疗，包括多脏器支持治疗、抗炎治疗，液体复苏、强化胰岛索治疗等治疗方法。因为病理生理机制方面的研究进展较少．脓毒血症的治疗也没有取得较大的突破。Ghrelin是最近发现的一种脑肠肽．同时也是生长激素促分泌受体的一种内源性配体。研究发现ghrelin能够在盲肠结扎穿孔所致的大鼠脓毒血症模型中减弱炎症反应、器官损伤和降低死亡率。本文主要关注ghrelin在脓毒血症中的作用机制，为ghrelin将来在脓毒血症中的应用提供线索。Sepsis manifests e high morbidity and high mortality. Comprehensive treatments including multiple organ support therapy, anti-inflammatory therapy, fluid resuscitation, intensive insulin therapy were emphasized to treat sepsis. Since the research on the pathophysiology of sepsis made slow progress, treatment of sepsis achieved little breakthrough. Ghrelin, an endogenous ligand of growth hormone secretagogue receptor, is a recently discovered brain-gut peptide. It was found that ghrelin could attenuate inflammatory response, organ injure and mortality in sepsis caused by cecal ligation and puncture rat model. In this review, we describe the mechanisms of ghrelin in treating sepsis and lay the foundation for ghrelin as a potential therapy for sepsis.

关 键 词：GHRELIN 脓毒血痉 盲肠结扎穿孔 

分 类 号：R459.5[医药卫生—治疗学]