鲍曼不动杆菌16SrRNA甲基化酶的研究进展  

Research Progress on 16SrRNA Methylases of Acinetobacter Baumannii

作　　者：张利娟[1] 郝邯生[2] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]中国人民武装警察部队医学院附属医院传染科,天津300162

出　　处：《医学综述》2011年第5期676-678,共3页Medical Recapitulate

摘　　要：氨基糖苷类抗菌药在治疗严重细菌感染,尤其是革兰阴性杆菌感染中发挥着重要的作用。鲍曼不动杆菌16SrRNA甲基化酶是近年来发现的一种新的耐药决定因子,介导对多种氨基糖苷类高水平耐药。目前在革兰阴性菌中已发现7种16SrRNA甲基化酶基因(armA、rmtA、rmtB、rmtC、rmtD、rmtE和npmA),鲍曼不动杆菌中仅发现armA。此类基因常位于质粒、Ⅰ类整合子或转座子上,引起耐药机制的传播。Aminoglycoside has played an important role on the treatment of life-threatening infections especially caused by Gram-negative bacilli bacterias.Recently,16SrRNA methylases in Acinetobacter baumannii,a novel aminoglycoside resistance determinant factor,confering a high level of resistance to various clinically important aminoglycosides has been discovered.At present,seven types of 16SrRNA methylases genes（armA,rmtA,rmtB,rmtC,rmtD,rmtE and npmA）has been found in members of the family gram-negative bacilli,while only armA that has been discovered in Acinetobacter baumannii.The genes are usually carried by plasmids,class Ⅰintegrons,transposons that can readily spread through bacterial populations.

关 键 词：鲍曼不动杆菌 氨基糖苷类 16SRRNA甲基化酶 ARMA 

分 类 号：R978.12[医药卫生—药品]