冠状动脉粥样硬化性心脏病患者脂蛋白(a)水平的相关研究  

Levels of Serum Lipoprotein(a) in Patients with Coronary Heart Disease

作　　者：程伟伟[1,2] 姚建民[1] 

机构地区：[1]北京军区总医院心肺中心一区,北京100700 [2]山西医科大学第二临床医学院,太原030001

出　　处：《医学综述》2011年第5期788-789,共2页Medical Recapitulate

摘　　要：目的探讨冠状动脉粥样硬化性心脏病(CHD)患者血清脂蛋白(a)[LP(a)]水平的差异,并分析血清LP(a)检测的意义。方法检测212例疑为CHD而住院患者的血清LP(a),并行冠状动脉造影(CAG)。根据冠状动脉造影结果将患者分为非CHD/CAG阴性组、CHD组;CHD组再按病变血管数、治疗方式不同分组。分析各组间血清LP(a)水平的差异。结果 CHD患者与非CHD患者相比,LP(a)水平明显升高(P<0.01);随着冠状动脉病变支数的增多,LP(a)亦升高(P<0.05或P<0.01);CHD不同治疗组与非CHD组比较,LP(a)升高(P<0.05或P<0.01)。结论 LP(a)作为CHD的独立危险因素,其水平与冠状动脉病变程度相关,可为CHD的临床诊断和治疗提供依据。Objective To study the possible diversity of serum lipoprotein（a）level in patients with coronary heart disease,and analyze the significance of LP（a）detection.Methods 212 patients who were suspected coronary heart disease（CHD）were studied.All patients were detected serum LP（a）and underwent coronary arteriography（CAG）.Based on the results of CAG,patients were divided into non-CHD group and CHD group.Then the CHD group was classified according to the number of coronary artery with stenosis and different treatment of CHD.The diversity of LP（a）levels was analyzed at last.Results Compared with non-CHD patients,the level of LP（a）in CHD patients was significantly increased（P0.01）.The level of Lp（a）increased with the number of damaged coronary（P0.05 or P0.01）.Compared with non-CHD patients,the levels of LP（a）in different treatment groups were rised（P0.05 or P0.01）.Conclusions an independent risk factor for CHD,the level of LP（a）is relevant to the damaged degree of coronary,and provide a basis for the clinical diagnosis and treatment of CHD.

关 键 词：脂蛋白(a) 冠心病 冠脉病变程度 治疗方式 

分 类 号：R654[医药卫生—外科学]