超临界流体快速膨胀法制备超细氟比洛芬粒子  

Preparation of Ultra-fine Particles of Flurbiprofen Using Rapid Expansion of Supercritical Solution

作　　者：刘永兵[1] 匡卓珺[1] 易健民[1] 刘杰[1] 

机构地区：[1]湖南理工学院化学化工学院,湖南岳阳414000

出　　处：《广东化工》2011年第3期217-218,212,共3页Guangdong Chemical Industry

基　　金：湖南省自然科学基金资助项目(07JJ3016);湖南省大学生研究性学习和创新性实验计划项目(sj201005);国家自然科学基金资助项目(21076068)

摘　　要：文章选用二氧化碳作为超临界溶剂,采用超临界溶液快速膨胀技术制备超细氟比洛芬药物粒子,在较宽的温度压力范围内测定了氟比洛芬在超临界二氧化碳中的溶解度,考察了各种操作参数对药物粒子粒径的影响,研究了药物粒子粒径随各种操作参数的变化规律。结果表明：在实验考察的范围内,氟比洛芬的溶解度较小,在10-5~10-7之间（摩尔分率）,溶解度随着温度和压力的升高而增大。同时实验结果表明：粒径随预膨胀压力的升高而减小;一定范围内随接收距离的增大而增大;在萃取温度较低的情况下,粒子粒径基本随着萃取温度的升高而减小;随着萃取温度的升高,在相对较高预膨胀温度下,粒径随着萃取温度升高而增大。This work was to prepare the ultra-fine particles of Flurbiprofen by using RESS（Rapid Expansion of Supercritical Solution）.The solubility of Flurbiprofen in supercritical CO2 was measured within a large pressure and temperature.The effects of temperature and pressure on the range of solubility were investigated.The RESS experiment for Flurbiprofen supercritical CO2 was carried out to clarify the effect of pre-expansion pressure,extraction temperature and collecting distance on the size of the formed particles.It was found that Flurbiprofen has poor solubility in SCF-CO2 and its solubility increases with the increasing of pressure and temperature.No retrograde area was found as reported in some literatures.In the RESS experiment,particles prepared were generally smaller,more uniform and better morphology than the starting material.Size of particles decreased with the increasing of pre-expansion temperature,and increased with the increasing of collection distance.In the case of low extraction temperature,size of particles decreased with the increasing of extraction temperature;as the relatively high pre-expansion temperature,size of particles increased with the increase of extraction temperature.

关 键 词：超临界流体快速膨胀法 超细粒子 氟比洛芬 CO2 

分 类 号：TQ021.3[化学工程]