壳聚糖硫酸盐催化合成苯佐卡因  

CATALYTIC SYNTHESIS OF BENZOCAINE WITH CHITOSAN SULFATE

作　　者：尹大伟[1] 刘玉婷[1] 

机构地区：[1]陕西科技大学化学与化工学院,陕西西安710021

出　　处：《陕西科技大学学报（自然科学版）》2011年第1期32-34,共3页Journal of Shaanxi University of Science & Technology

摘　　要：采用壳聚糖硫酸盐催化合成苯佐卡因(对氨基苯甲酸乙酯),讨论了催化剂用量、体系pH、反应时间和回流温度对酯产率的影响,确定了最佳的反应条件:体系pH=2,催化剂用量0.8 g(对氨基苯甲酸0.01 mol),反应时间4 h,回流温度65℃,苯佐卡因产率为86.8%.壳聚糖硫酸盐具有良好的催化性能,反应条件温和,无废酸产生,无腐蚀,而且可以重复使用.Benzocaine was synthesized using chitosan sulfate as catalyst.Simultaneously,the effect of some factors,such as the amount of catalysts,pH,time and reaction temperature on the yield of benzocaine were studied.The experiment results affirmed the best reaction conditions： pH=2,the mass of chitosan sulfate was 0.8 g,reaction tiome was 4 h,refluxing temperature was 65 ℃,the yield of benzocaine was 86.8%.Using chitosan sulfate in synthesis of benzocaine,the reaction condition was mild,nonexpendable,non-corrosive,and can be reused.

关 键 词：壳聚糖硫酸盐 催化 苯佐卡因 合成 

分 类 号：TQ245.12[化学工程—有机化工] TQ203.2