肠病及肺的微生态学研究  

Study on the Microecology of "Bowel Disease and Lung"

作　　者：叶建红[1] 杨宇[1] 郑旭锐[1] 冯贤荣[1] 朱素有[1] 张显明[1] 周新颖[1] 

机构地区：[1]成都中医药大学,四川成都610075

出　　处：《云南中医中药杂志》2011年第3期54-55,2,共2页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：国家重点基础研究发展计划(973计划)资助项目(编号:2009CB522706)

摘　　要：目的:采用微生态学的研究方法探讨"肠病及肺"的机理。方法:建立大鼠便秘模型,观察其结肠和肺部微生态变化。结果:便秘模型组的肠道需氧菌、真菌、大肠杆菌较正常对照组显著增多(P<0.01),而厌氧菌、类杆菌和双歧杆菌显著减少(P<0.01);同时,便秘模型组的肺部需氧菌增多,厌氧菌显著减少(P<0.05),真菌显著增多(P<0.01)。结论:肺肠微生态学上的菌群对应规律性变化可能是"肠病及肺"的机制之一。Objective: To study the mechanism of bowel disease and lung micro-ecologically.Methods: Rat constipation models were made to observe the microbial changes in the colon and lung of the rats.Results: The number of aerobe,fungi and E.coli in the constipation model significantly increased than that in normal group(P<0.01) while the number of anaerobes,bacteroid and bifidobacterium significantly reduced(P<0.01).At the same time the number of lung aerobe increased in the constipation group,anaerobes significantly reduced(P<0.05) and fungi significantly increased(P<0.01).Conclusion: The flora in the pulmonary intestinal micro-ecology corresponding to regular changes may be one of the mechanism of the 'bowel disease and lung'.

关 键 词：肺与大肠相表里 肠病及肺 便秘 微生态学 

分 类 号：R37[医药卫生—病原生物学]