复方曲肽注射液对血小板聚集和血栓形成影响的实验研究  

Effect of Troxerutin and Cerebroproptein Hydrolysate Injection on Platelet Aggregation and Thrombosis

作　　者：陈秋晨[1] 于兆进[1] 孙海刚[1] 于涧坤[1] 魏敏杰[1] 

机构地区：[1]中国医科大学药学院药理教研室,辽宁沈阳110001

出　　处：《中国实验血液学杂志》2011年第1期193-196,共4页Journal of Experimental Hematology

摘　　要：本研究探讨受试药物复方曲肽注射液的体外抗血小板聚集及体内抑制血栓形成的作用。采用血小板凝聚仪测定不同浓度复方曲肽注射液对血小板聚集的抑制率,并确定量效关系。采用动脉短路血栓模型测定复方曲肽注射液的抑制血栓形成作用。结果表明,复方曲肽注射液具有抑制血栓形成作用和剂量依赖性的抗血小板聚集功能。当复方曲肽溶液总氮终浓度为5μg/m l时,血小板聚集抑制率达到(28.61±22.07)%,其最大活性为100μg/m l的阿司匹林溶液抗血小板聚集活性的2.5倍。复方曲肽注射液的血栓形成抑制率为(33.90±17.56)%。结论:复方曲肽注射液具有抗血小板聚集和抑制血栓形成的作用。This study was purposed to explore the effect of troxerotin and cerebroprptein hydrolysate injection（TCHI） on platelet aggregation in vitro and thrombosis in vivo.The inhibitory rate of TCHI at different concentrations on platelet aggregation was determined by platelet aggregometer.The relationship between dose and effect was established.The effect of troxerutin and cerebroproptein hydrolysate injection on thrombosis was determined by the carotid thrombosis model of rats.The results showed that the TCHI could inhibit thrombosis and platelet aggregation in a concentration-dependent way.When the concentration of TCHI total nitrogen was 5 μg/ml,the inhibition rate of platelet aggregation reached to the highest value of 28.61±22.07%,which is 2.5 times as much as that with 100 μg/ml aspirin.It is concluded that the TCHI has antiaggregative and antithrombotic activity effects against platelet aggregation and thrombosis.

关 键 词：血小板聚集 曲肽 血栓模型 

分 类 号：R558[医药卫生—血液循环系统疾病] R364.15[医药卫生—内科学]